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Thorne   5-MTHF 5 mg - 60 Capsules

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  • 4.8
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30 Reviews

"Excellent product"  Read all reviews

Item Number: TR1337
Serving Size: 1 Capsule Servings per Container: 60
Price per Serving:  $0.92 Price per Unit*: $0.92 per Capsule
* Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
82 In Stock.

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Active folate supplementation for mood‚ heart health‚ fetal development and nerve support

5-MTHF is an active‚ tissue-ready form of folate. It's an essential B vitamin that supports methylation. Many individuals don't get sufficient 5-MTHF because they have intestinal or liver dysfunction or because of their genetic makeup.


Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate)‚ the active form of folic acid‚ because they have intestinal or liver dysfunction‚ or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF. A deficiency of folic acid has been linked to low-birth-weight infants and neural tube defects‚ which is why the Centers for Disease Control recommends folic acid supplementation for all women of childbearing age. Since 5-MTHF also contributes to the production of serotonin‚ melatonin‚ dopamine‚ epinephrine‚ and norepinephrine‚ supplementation supports healthy mood.

Note: 1 mg of 5-MTHF is recommended for fetal support during pregnancy; the 15 mg option is recommended only when directed by a health-care practitioner.

It is important for a woman of childbearing age to get enough folic acid – not just those women who are planning to become pregnant. Because half of pregnancies are unplanned‚ any woman who could become pregnant should get enough folic acid every day. Folic acid intake is especially important before conception and during early pregnancy‚ since its biggest need is during the first trimester – when a woman might not even know she is pregnant. Supplementation with the active form of folic acid – 5-MTHF (L-5 Methyltetrahydrofolate)– is always preferable.

Acting with vitamin B12‚ 5-MTHF functions as a methyl-group donor‚ thereby facilitating the conversion of the amino acid homocysteine to methionine. An elevated homocysteine level is a risk factor for a number of undesirable health conditions. Methyl-group donation is vital to many biochemical conversion processes‚ including the synthesis of serotonin‚ melatonin‚ and DNA.



These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

  • MFG # B132
  • UPC # 693749132011
Official Website: https://www.thorne.com

Servings Size: One Capsule
Servings Per Container: 60

One Capsule Contains / % DV

Folate (5 mg as L-5-Methyltetrahydrofolate†) 8.3 mg DFE / 2‚075%

Daily Value (DV)

Other Ingredients: Microcrystalline Cellulose‚ Hypromellose (derived from cellulose) capsule‚ Leucine‚ Silicon Dioxide.

†This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S®). Extrafolate-S is a registered trademark of Gnosis S.p.A.

Gluten Free.


Take 1 capsule two to three times daily or as recommended by your health professional.


ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PREGNANCY WARNING
If pregnant‚ consult your health professional before using this product.

INTERACTIONS
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy‚ as it can interfere with methotrexate's anti-neoplastic activity; however‚ this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

TAMPER EVIDENT
Use only if bottle is sealed. Store tightly sealed in a cool‚ dry place.


  • Egg Free
  • Gluten Free
  • High Fructose Corn Syrup Free
  • Nut Free
  • Peanut Free

Ratings and Reviews

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  • 4.8
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5 30
  • 30 Reviews
    • Verified Buyer

      Very high quality methylfolate

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      from Arizona on 3/15/2021
      Was a game changer in addressing fatigue and energy.

      Pros

      Quality, purity

      Cons

      None
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Makes a difference even though pricey

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      from LA on 11/17/2020
      My doctor had me start taking this 5-MTHF a couple years ago. I can't pinpoint exactly what the difference this 5-MTHF makes is, but I can tell when I stop taking it!

      Pros

      makes a positive difference in how I feel

      Cons

      very expensive
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Does what it is supposed to do.

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      from KAILUA KONA HI on 9/26/2020
      Thorne is a great brand.

      Pros

      High potency.

      Cons

      N/A
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Good Product, and reputable company

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      from Spokane WA on 10/28/2019
      Good product for genetic mutation MTHFR. Like Thorne products. Always good service with Pure Formulas.
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Game Changer!!!

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      from Seattle, WA on 10/02/2019
      Immediate benefits from this amazing supplement.

      Pros

      Immediate energy, long lasting

      Cons

      Price
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Methylated is the way to go

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      from Portland OR on 7/25/2019
      Unless the B vits are methylated, you may as well just be throwing good money after bad. I love THORNE brand. It's the real dealio.
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Good brand

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      from Virginia on 4/16/2019
      I trust Thorne products, and taking a 5-MTHF brand of this B vit - I wouldn't take folate as folic acid - is important and preferred for most. It's a bit expensive

      Pros

      folate is better than folic acid, good brand

      Cons

      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Great product

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      from Mason NH on 4/04/2019
      Pure and simple. This is a must-have in my household.
      review-checkI would recommend this item to a friend.
    • Just what I wanted!

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      from NJ on 2/06/2018
      I've been taking 5-MTHF by Thorne Research for 14 months. It is not easy to find. The service was good and the price reasonable.
      review-checkI would recommend this item to a friend.
    • Verified Buyer

      Prescribed by Naturopath!

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      from Middletown on 11/17/2015
      I'm not sure if 5 MTHF by Thorne Research works but I'm doing a little better. Apparently a mutated gene causes folate not to be methylated. The MTHR gene. A blood test is required to find out if you have it.

      Pros

      Seems to help.

      Cons

      It is expensive.
      review-checkI would recommend this item to a friend.
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Customer Questions and Answers

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  • Question:
    Is this product equivalent to Deplin? My doctor prescribed Deplin but it is prohibitively expensive and I was hoping this might be a good alternative.
    joy Dixon on 9/30/2014 Answer:
    • Hello, thank you for contacting PureFormuals. Your health professional would be the one that would be the one that can recommend the product to you.
      Rosa on 10/01/2014

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