- MFG # 0309-120
- UPC # KM1049
Many clinicians are now utilizing higher doses of Trimethylglycine (TMG). For individuals whose doctors recommend these higher dosages‚ Kirkman® offers a 500 mg TMG capsule with Folinic Acid and Methyl B-12 that will minimize the number of capsules needed to meet the physicians’ recommended intake. This is a hypoallergenic formulation‚ specially designed for individuals with special requirements and sensitivities.
Folic acid intake and levels in the body must be adequate for TMG to work biochemically. To be active in the body‚ folic acid needs to be reduced twice by folate reductase enzymes‚ is then converted to tetrahydrofolate‚ after which a methyl group is added to the tetrahydrofolate. In some individuals‚ the use of natural folinic acid may be more beneficial than folic acid‚ because folinic acid already has attached four hydrogen atoms and one methyl group‚ thereby shortcutting the complicated biochemical processes that assist purine and nucleotide synthesis‚ which are so important in cell perception and response. For that reason‚ some doctors are recommending TMG with folinic acid instead of the folic acid form of folate.
Because folic acid can sometimes mask a vitamin B-12 deficiency‚ vitamin B-12 has also been included in this formulation. Furthermore‚ it is known that vitamin B-12 works synergistically with folic acid. The most active form of vitamin B-12 in folate chemistry is methylcobalamin‚ and Kirkman® utilizes this form of vitamin B-12 in this product‚ which may assist methionine metabolism‚ methylation and folate chemistry.
Kirkman’s trimethylglycine (TMG) is derived from beets‚ which is the commercially available source. TMG is dimethylglycine (DMG) with one more methyl group. The chemical structure of TMG is a glycine molecule holding onto three methyl groups. Like DMG‚ TMG is considered a "methyl donor" or “methyl bank." The additional methyl group makes TMG a more active methyl donor than DMG‚ which provides a benefit to some individuals. TMG can support the formation of methionine by methylating homocysteine. Some of this methionine eventually is converted into SAMe (S-adenosylmethionine)‚ which can help maintain healthy serotonin levels in the body‚ thus supporting mood and a feeling of well-being.
As with DMG‚ TMG plus a coenzyme of riboflavin supplies methyl groups that attach to folic acid to form methylenetetrahydrofolate‚ an important component of many biochemical processes in the body including cellular perception and response.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 Capsule
Amount Per Serving / % DV
Folinic Acid (calcium folinate) 400mcg / 100%
Vitamin B-12 (methylcobalamin) 6mcg / 100%
Trimethylglycine (TMG) 500mg / *
*Daily Value not established.
Trimethylglycine‚ Di-calcium phosphate‚ calcium folinate‚ magnesium stearate (vegetable)‚ methylcobalamin‚ plant cellulose capsule.
Casein‚ gluten‚ soy‚ yeast‚ milk‚ sucrose‚ preservatives‚ flavorings‚ colorings‚ gelatin‚ egg‚ peanuts‚ tree nuts or fish.
1-2 capsules daily or as directed by a physician.
Store in a cool dry place.
Keep out of the reach of children.
Allergy / Dietary Needs
- Artificial Color Free
- Artificial Flavor Free
- Casein Free
- Corn Free
- Egg Free
- Fish Free
- Gluten Free
- Milk Free
- Peanut Free
- Preservative Free
- Soy Free
- Starch Free
- Sugar Free
- Tree Nuts Free
- Wheat Free
- Yeast Free
Ratings & ReviewsReview This Item
Overall Rating for TMG 500 mg with Folinic Acid & Methyl B-12 -Hypoallergenic - 120 Capsules
from LA, CA
Great for Environmental Allergies
This supplement has alleviated our kids environmental allergies significantly. We also like it that it has folinic acid instead of folate since we have problems with folate.
√ I would recommend this item to a friend.
from New Mexico
I ordered TMG 500 mg with Folinic Acid & Methyl B-12 for my 2 year old son who has autism. This product was recommended by my Defeat Autism Now doctor. We have just started it and I am hoping it will help him with his speech.
√ I would recommend this item to a friend.
Questions About This ItemAsk a Question
Displaying questions 1-1 of 1
Jeannette on 10/06/2014
Is it OK to open capsules and add to food?A
Rosa on 10/07/2014
Hello, thank you for contacting PureFormulas. The bottle does not indicate but you can try contacting the manufacturer of the product. Have a wonderful day.
- Rosa on 10/07/2014