- MFG # 01055
- UPC # 737870105558
SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:
Methylation (contributing methyl groups to activate certain molecules)
The synthesis of polyamines (for cell growth‚ gene expression‚ neuronal regeneration‚ etc.)
Trans-sulfuration (synthesis of cysteine‚ glutathione‚ and other sulfate chemicals)
SAMe occurs naturally in the body. It is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones‚ nucleic acids‚ proteins‚ and phospholipids‚ catecholamines‚ and other neurotransmitters‚ such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine‚ dopamine‚ and serotonin‚ and also plays a role in other intracellular metabolic pathways. SAMe facilitates glutathione usage and maintains acetylcholine levels‚ which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.
SAMe levels may become depleted from sickness and age. Supplementation with the cofactors — folate‚ trimethylglycine (TMG or betaine)‚ vitamins B6 and B12‚ together with SAMe — appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine‚ which keeps cell membranes fluid‚ and is used in the brain to make the neurotransmitter acetylcholine.
In 2002‚ an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Its findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects.33 Since aging people often suffer joint discomfort and immobilization‚ SAMe addresses multiple problems people face as they grow older. In addition‚ SAMe has multiple mechanisms of action that are used throughout the body‚ especially in the liver‚ which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione. When liver function is compromised‚ glutathione is depleted‚ which leads to free radical damage.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size 1 tablet
Servings Per Container 50
Amount Per Serving
S-Adenosyl-Methionine 400 mg
Other ingredients: cellulose‚ mannitol‚ hydroxypropyl methylcellulose phthalate‚ citric acid‚ silica‚ stearic acid‚ glyceryl triacetate‚ sodium starch glycolate‚ croscarmellose sodium‚ titanium dioxide‚ yellow ochre.
Take one tablet two to three times daily in divided doses‚ preferably on an empty stomach. Take with co-factors vitamins B12‚ B6‚ and folic acid.
SAMe should not be taken by those diagnosed with bipolar disorder.
Keep out of reach of children. Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged. When using nutritional supplements‚ please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Store tightly closed in a cool‚ dry place.
Ratings & ReviewsReview This Item
Overall Rating for SAMe (S-adenosyl-methionine) 400 mg - 50 Tablets
from United States
Husband uses this
I see a huge difference in him since he started taking it. He wants to keep taking it and it makes me happy!
Has to be taken 1/2 hour before food or something like that. hard to manage sometimes.
√ I would recommend this item to a friend.
Questions About This ItemAsk a Question
Please ask any questions you may have about this specific product in the field below.
Your question(s) and our corresponding answer(s) will not be confidential and will be posted publically on this specific product page.
Additionally, PureFormulas is unable to directly recommend products in relation to specific health conditions. Please contact your trusted healthcare practitioner for direct product recommendations.
If you have any general questions regarding orders or our policies and programs, please contact our Customer Happiness Team @ 1.800.383.6008Please log in to submit a question.