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SAM-e 400 mg (Double Strength) - 30 Tablets


"SAM-e helped my joint pain. Will buy for my arthritic mother."  Read All Reviews

  • Brand: Doctor's Best
  • Item Number: DRB1000
  • Serving Size: 1 Tablet
  • Servings per Container: 30
  • Quantity per Container: 30 Tablets
  • Price per Serving:  0.85
  • Price per Unit*: $0.85 per Tablet
  • * Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
Availability: 11 In Stock
Regular Price:  43.19 25.52
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This item will ship on Monday when ordered after 5pm EST

  • MFG # DRB-00151
  • UPC # 753950001510

  • Suitable for vegetarians

    Science-based nutrition

    Dietary supplement

    Enhances mood and neural function

    Promotes joint comfort and mobility

    Supports liver health and detoxification

    Our SAMe 200 contains 200 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S‚S form per serving‚ bar none.

    S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver‚ joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

    Supplementing with SAMe

    The manufacturing process of SAMe yields two forms‚ the S‚S and the R‚S isomers. The S‚S isomer is the active form that mediates biochemical activity in the human body‚ whereas the R‚S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S‚S form on the market.

    SAMe and Joint Function

    SAMe may enhance cartilage protection and promote the synthesis of proteoglycans‚ essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement‚ and promote joint comfort.

    SAMe and Neural Health

    SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters‚ which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine‚ supporting cognitive function.

    SAMe and Liver Function

    SAMe enhances liver synthesis of glutathione‚ an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

    These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Official Website: http://www.drbvitamins.com

Serving Size: 1 Tablet

Serving per container: 30 servings

Amount Per Serving %DV

S-Adenosyl Methionine 400 mg †
(from 800 mg of SAM-e tosylate disulfate)


Other Ingredients: Cellulose gel‚ methacrylic acid copolymer‚ compritol 888ATO‚ talc‚ triethyl citrate‚ titanium dioxide‚ magnesium stearate‚ mannitol‚ glycerol palmitostearate‚ silica‚ medium chain triglycerides‚ sodium starch glycolate‚ and iron oxide.

The SAMe found in Doctor's Best SAMe 400mg is free from yeast‚ dairy‚ gluten‚ soy‚ wheat‚ and artificial flavoring.

Take 1 tablet daily away from food‚ or as directed by a health care professional. Do not chew or crush tablet.

Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

  • Dairy Free
  • Gluten Free
  • Soy Free
  • Wheat Free
  • Yeast Free

Ratings & Reviews

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Overall Rating for SAM-e 400 mg (Double Strength) - 30 Tablets

  • Average Rating: 5.0
5 2

Displaying reviews 1-2 of 2

  • By
    from Texas



    Verified Buyer

    Incredible results!

    I've been taking SAM-e by Doctor's Best for about 2 months now and I have felt a big change (Dr. recommendation). No more sadness or depression and better focus.


      It's gentle with my stomach and enhances mood really fast.


      The size of the pills.

    I would recommend this item to a friend.

  • 1 of 1 people found the following review helpful.

    from Coral Gables, FL



    Good for joints

    SAM-e helped my joint pain. Will buy for my arthritic mother.

    I would recommend this item to a friend.


Displaying reviews 1-2 of 2

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If you have any general questions regarding orders or our policies and programs, please contact our Customer Happiness Team @ 1.800.383.6008

If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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