- MFG # 10441
- UPC # 683268104415
WHAT IS CITRULLINE?
• Citrulline‚ a non-essential amino acid synthesized in the intestinal tract from Glutamine‚ converts to Arginine in a biochemical process involving Aspartic Acid and two necessary enzymes‚ Ornithine Transcarbamoylase and Argininosuccinate Synthetase. As a precursor to Arginine‚ it has a sparing effect on Arginine enabling an increase in Nitric Oxide production. Nitric Oxide (NO) is very important for endothelial support and cardiovascular health. Citrulline increases energy and stimulates the immune system‚ as well.
• Citrulline is also an essential component of the Urea Cycle‚ and functions along with Ornithine and Arginine to convert ammonia into Urea. High ammonia levels are extremely toxic and can cause liver damage and neurological impairment. Supplementation with Citrulline has been very beneficial in a genetic disorder called Ornithine Transcarbamoylase (OTC) Deficiency.
CITRULLINE AND CARDIOVASCULAR HEALTH
Citrulline is a precursor to Arginine‚ which has been shown to increase Nitric Oxide. Since up to 80% of Arginine is utilized in the liver and kidneys‚ only 20 % is available for cardiovascular support. Supplementing with Citrulline produces a sparing effect allowing for additional Arginine production intracellularly for cardiovascular function. Nitric Oxide (NO)‚ the endothelial relaxing factor (EDRF)‚ is a small molecule made from Arginine. It plays an essential role in the regulation of vascular homeostasis‚ modulates cardiac contractility‚ regulates vascular tone‚ and helps in preventing vessel injury and Atherosclerosis. Oxidative stress (free radicals damage) creates injury to endothelial cells. Citrulline converts to Arginine in the vascular cells‚ and thus increases Nitric Oxide production‚ which can help to restore endothelial cell function. The role of Nitric Oxide and Arginine supplementation‚ as well as the role of Citrulline in endothelial function has been well-documented in medical studies. Dr. S. Gross (Cornell U. Med. College) in his publication in the J. Biol. Chem.‚ 1997 suggests the ratio of 3 Arginine to 1 Citrulline
for Nitric Oxide production.
• Those with active Herpes who need cardiovascular support should reverse the Citrulline/Arginine ratio to 3 Citrulline to 1 Arginine‚ since Arginine can stimulate the Herpes‚ and similar viruses. This ratio can help increase Arginine intracellularly. Lysine supplementation may also be advisable in some cases.
ORNITHINE TRANSCAR BAMOYLASE (OTC) DEFICIENCY
This is a serious genetic Urea Cycle disorder effecting an estimated 1 in 20‚000 births. Ornithine ranscarbamoylase is the second enzyme in the Urea Cycle and is necessary to produce Citrulline. A deficiency of this enzyme Pauses a lack of Citrulline‚ thus the Urea Cycle cannot function properly and the result is hyperammonemia. It has been linked to SIDS deaths in newborns‚ and Reye's syndrome in children‚ since it is often undiagnosed. Symptoms of the neonatal onset disorder may appear in first 24 hours of life with vomiting and lethargy‚ followed by neonatal seizures and coma. This disorder often presents in males in the neonatal period‚ although partial enzyme deficiencies also affect both males and females in childhood and adulthood. This late onset form of the disorder may present In childhood with recurrent symptoms including lethargy‚ migraine-like headaches‚ persistent vomiting‚ dehydration‚ hyperactivity‚ bouts of screaming‚ acute taxia‚ retardation and coma. There are cases of female carriers of this disorder developing symptoms as adults as well. If untreated‚ it is 100% fatal‚ and there is no known cure. Limiting dietary protein‚ special formulas and Citrulline supplementation are advised to increase Urea Cycle function and reduce ammonia.
Ingredients per capsule:
Pure L-Citrulline 600 mg.
Take 1-3 capsules three times a day‚ or as needed.
Do not take with milk or dairy products.
Allergy / Dietary Needs
- Artificial Color Free
- Artificial Flavor Free
- Binders Free
- Corn Free
- Egg Free
- Fish Free
- GMP Certification
- Milk Free
- Preservative Free
- Salt Free
- Starch Free
- Sugar Free
- Wheat Free
- Yeast Free
- Animal By-Products Free
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