Optimized Folate (L-Methylfolate) 1000 mcg - 100 Vegetarian Tablets

by Life Extension
  • 4.8
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"Excellent product! High quality!"  Read all reviews

Item Number: LE1234
Serving Size: 1 Tablet Servings per Container: 100
Price per Serving:  $0.11 Price per Unit*: $0.11 per Tablet
* Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
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Metabolically Active Form of Folic Acid.

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine‚ folate benefits cardiovascular health and nervous system function.

Those who take ordinary folic acid supplements‚ however‚ may not be experiencing its full spectrum of effects. This is because folic acid is itself not biologically active‚ but its biological importance is due to its active form called 5-methyltetrahydrofolate (5-MTHF) after its conversion to dihydrofolic acid in the liver. Research shows that in a large proportion of the population‚ genetic dihydrofolate reductase enzyme deficiencies limited the conversion of folate to 5-MTHF‚ leaving many vulnerable to low blood 5-MTHF levels (and higher than desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly‚ which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate levels compared with folic acid supplementation. 5-MTHF is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since 5-MTHF requires no conversion to be biologically active.

People with elevated homocysteine levels have a greater risk of cognitive decline. Unlike folic acid‚ 5-MTHF is able to cross the blood-brain barrier‚ which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12)‚ vitamin B6‚ and riboflavin.

Optimized Folate now provides Quatrefolic® 5-methyltetrahydrofolate complexed with glucosamine for longer stability‚ higher water solubility and improved bioavailability compared to other forms of 5-MTHF.



These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

  • MFG # 01939
  • UPC # 737870193913
Official Website: https://www.lifeextension.com

Serving Size: 1 Vegetarian Tablet

Amount Per Serving / % DV

Folate [As (6S)-5-Methyltetrahydrofolic Acid‚ glucosamine salt] 1‚000mcg / 250%

Other Ingredients: Microcrystalline cellulose‚ dicalcium phosphate‚ croscarmellose sodium‚ silica‚ vegetable stearate‚ stearic acid.

Non-GMO.

Take one (1) tablet daily with food‚ or as recommended by a healthcare practitioner.

Keep out of reach of children. Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged. When using nutritional supplements‚ please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. Store tightly closed in a cool‚ dry place.

  • GMO Free
  • Vegetarian

Ratings and Reviews

Write a Review
  • 4.8
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5 22
  • 22 Reviews
    • Verified Buyer

      Easy to swallow

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      from MAGNOLIA TX on 11/20/2019
      I take this regularly since I have MTHFR gene mutation. It is a small tablet and easy to swallow.

      Pros

      small tablet, easy to swallow

      Cons

      I would recommend this item to a friend.
    • Verified Buyer

      Optimal Nutrition Support!

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      from USA on 9/15/2019
      Positive effect is noticeable within 1-5 days! I take this with SAM-e and Methylcobalamin B12 to assist the full methionine cycle and prevent both B12 deficiencies and dangerous homocystine excesses. I have MTHFR SNP mutations, and treatment-resistant neurodiversities, and this provides symptom relief and improves my overall health. Please note that 5-methyl-folate is the more bioactive form of folic acid. This is the form that folic acid takes in the body, after being processed by the non-mutated MTHFR gene. Taking this form of folic acid bypasses any MTHFR SNP mutations that prevent the body from effectively processing the nutrient.

      Pros

      This small uncoated tablet is easy to swallow, easy to cut if you need a smaller dose, crushed easily and dissolves well in water for those with problems swallowing. It is free of sugar, propylene glycol, and the top 9 allergens. This brand has reliable high quality and the lowest price for the dosage, of any currently available OTC Methylfolate product. It is difficult to overdose on this vitamin.

      Cons

      Methyl-folate supplementation can hide the clinical signs of B-12 deficiency, so combination supplementation is your safest option. There is no current medically recommended effective dosage of Methylfolate, so experimentation is required to fine one's correct personal dosage. Overdose oPositive effect is noticeable within 1-5 days! I take this with SAM-e and Methylcobalamin B12 to assist the full methionine cycle and prevent both B12 deficiencies and dangerous homocystine excesses. I have MTHFR SNP mutations, and treatment-resistant neurodiversities, and this provides symptom relief and improves my overall health. Please note that 5-methyl-folate is the more bioactive form of folic acid. This is the form that folic acid takes in the body, after being processed by the non-mutated MTHFR gene. Taking this form of folic acid bypasses any MTHFR SNP mutations that prevent the body from effectively processing the nutrient.f this nutrient has been shown to cause many of the same symptoms as a deficiency.
      I would recommend this item to a friend.
    • Verified Buyer

      Doesn't seem to work for me...

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      from CT on 3/06/2018
      I asked my psychiatrist if there were any supplements I could take that would help with depression without interfering with my medications, and she recommended Optimized Folate by Life Extension. I have been taking this every day along with my usual medications, and I haven't noticed a difference, so I don't think I'll be repurchasing at this time. If I notice a change for the worse after I stop taking it, maybe I will try it again.

      Pros

      Not too sure...

      Cons

      Possibly ineffective.
    • Verified Buyer

      Added to daughter’s regimen

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      from HAZLEHURST GA on 1/31/2018
      This Optimized Folate (L-Methylfolate) 1000 mcg by Life Extension comes in an easy to swallow size. It is a quality product.

      Pros

      The price was great. I believe in the quality of this brand.

      Cons

      Nothing
      I would recommend this item to a friend.
    • Verified Buyer

      Great product!

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      from COLUMBUS OH on 12/23/2017
      My physician recommended Optimized Folate (L-Methylfolate) 1000 mcg by Life Extension to help with anxiety and a disorder that I have called trichotillomania. It has really helped!

      Pros

      It really helps me.

      Cons

      Wish the price was a little less, but will pay more for good quality.
      I would recommend this item to a friend.
    • Verified Buyer

      Pure product

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      from La Pine OR on 10/20/2017
      Optimized Folate (L-Methylfolate) 1000 mcg by Life Extension has helped my folic levels.
      I would recommend this item to a friend.
    • Verified Buyer

      The best!

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      from Arizona on 3/25/2016
      My doctor suggested I take Optimized Folate by Life Extension and I am so grateful she did. I take it every morning and can really tell the difference. It's amazing!

      Pros

      The small tablet is easy to swallow. This brand works better than others I have tried before.

      Cons

      There is nothing that I dislike about this product and I would highly recommend it.
      I would recommend this item to a friend.
    • Verified Buyer

      Don't Be Confused.

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      from Calabasas, CA on 3/14/2016
      Folate and folic acid are not the same; so, when my physician recommended Optimized Folate by Life Exension, I researched, and shopped hardy! Best price, fast delivery, and just what the doctor ordered.
      I would recommend this item to a friend.
    • Verified Buyer

      Lightens my mood!

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      from davis, ca on 10/05/2015
      At the suggestion of a friend, I tried Optimized Folate L-Methylfolate by Life Extension. They are wonderful. I suffer from Major Depressive Disorder and I am treatment resistant, but the product above makes a discernible difference in severity of depressive symptoms. I understand it may not work for everyone, but it certainly works for me.

      Pros

      Eases symptoms of major depressive disorder.

      Cons

      Nothing. :)
      I would recommend this item to a friend.
    • Best form of folate!

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      from Georgia on 4/17/2015
      I like that Optimized Folate by Life Extension is the best form of folate and great for someone with MTHFR gene. The capsules are easy to swallow and the strength is high, which I like.
      I would recommend this item to a friend.
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If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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