- MFG # 53272
- UPC # 716963532723
Melatonin is a natural lipophilic hormone secreted by the pineal gland in the brain‚ and is classified as an indoleamine. Closely involved in the natural sleep cycle‚ Melatonin can help support restful sleep patterns. Melatonin may be appropriate for people experiencing occasional sleeplessness‚ those with jet lag or those wanting to promote sound‚ quality sleep. These positive findings are most likely mediated through Melatonin’s involvement with membrane-bound receptors located in the suprachismatic nucleus‚ the pars tuberalis‚ and other brain regions.
The pineal gland is the organ where information about light and dark is processed and then relayed to cells throughout the body. The eyes deliver information to the pineal gland through different routes that include the retinohypothalamic tract and the suprachiasmatic nuclei. Norepinephrine released from postganglionic nerve endings to the pineal gland helps control melatonin release. This release of norepinephrine to the pinealocytes occurs at night‚ which is when melatonin secretion and levels throughout the body begin to rise.
Melatonin‚ due to its considerable lipophilicity‚ is able to cross any cell membrane and enter any tissue or cellular compartment. Therefore it is likely that some of melatonin's biochemical effects are elicited through intracellular binding sites in addition to its interactions with membrane-bound receptors (Hardeland‚ 95). Melatonin's high lipophilicity is what allows it to transmit the signal of darkness to every cell in the body‚ in turn acting as the eyes for each cell‚ organ and tissue. This is why melatonin levels throughout the body are so important for promoting calm‚ restful sleep and a relaxed mood in the evening by supporting natural circadian rhythms.
In addition to its effects on sleep‚ Melatonin is believed to play a major role in the biological termination of free-radical induced redox reactions. Melatonin is reported to have a large capacity to trap hydroxyl radicals‚ the free radical species with the highest relative reactivity. Melatonin also efficiently traps peroxyl radicals and superoxide anions. Melatonin participates in a two-step process in which it first interacts with a hydroxyl or peroxyl radial to give a melatonyl cation radical‚ which then combines with a superoxide anion to neutralize the electrical charges and pairing electrons.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 Capsule
Amount Per Serving / % DV
Melatonin 10mg / **
**Daily Value not established.
Other Ingredients: Rice flour‚ gelatin. Contains <2% of silica‚ vegetable magnesium stearate.
Free of artificial color‚ artificial flavor‚ artificial sweetener‚ preservatives‚ sugar‚ milk‚ lactose‚ soy‚ gluten‚ wheat‚ yeast‚ fish‚ sodium.
For adults‚ take one (1) capsule at bedtime as Melatonin may produce drowsiness. As a reminder‚ discuss the supplements and medications you take with your healthcare providers.
Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition‚ consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Do not drive‚ operate machinery or consume alcohol when taking this product. Limit use to two months with a break of one week. Not intended for use by persons under the age of 18. Keep out of reach of children. Do not use if seal under cap is broken or missing. Store at room temperature and avoid excessive heat.
Allergy / Dietary Needs
- Artificial Color Free
- Artificial Flavor Free
- Artificial Sweeteners Free
- Dairy Free
- Fish Free
- Gluten Free
- Lactose Free
- Milk Free
- Preservative Free
- Sodium Free
- Soy Free
- Starch Free
- Sugar Free
- Wheat Free
- Yeast Free
Ratings & ReviewsReview This Item
Overall Rating for Melatonin 10 mg - 120 Capsules
By Renita Harman
from Harrisonburg VA
Works great! So glad to be sleeping!
I chose Melatonin by Physiologics because my regular Melatonin I usually order was out of stock.
I like that it's a 10 mg so I only have to take one pill. Has helped me slept straight through the night ! Which of you have problems sleeping you know how great that is!!!
√ I would recommend this item to a friend.
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