Thorne   5-Hydroxytryptophan - 90 Capsules

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"My ND recommended this for help with falling asleep and mood regulation. I also ..."  Read all reviews

Item Number: TR1228
Serving Size: 2 Capsules Servings per Container: 45
Price per Serving:  $0.76 Price per Unit*: $0.38 per Capsule
* Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
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Enhances sleep and helps manage stress*

5-HTP increases serotonin levels to promote restful sleep‚ manage stress‚ and decrease sugar cravings.* It contains pyridoxal 5'-phosphate‚ the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin.

The serotonin levels in the body are associated with the regulation of sleep‚ mood‚ and appetite. A balanced serotonin level has been shown to support restful sleep‚ good mood‚ and decreased sugar cravings. There are several ways to support a healthy serotonin level. L-tryptophan and 5-Hydroxytryptophan (5-HTP) are both precursors to serotonin. However‚ supplementation with 5-HTP is preferable‚ because unlike L-tryptophan‚ 5-HTP cannot be shunted into other uses in the body‚ such as niacin or protein production. 5-HTP is well absorbed by the body and easily crosses the blood-brain barrier where it can increase the synthesis of serotonin in the central nervous system. And 5-HTP can be taken with meals without reducing its effectiveness.

5-Hydroxytryptophan (5-HTP) is the intermediate metabolite the body produces when it initiates the process of converting the essential amino acid L-tryptophan to serotonin. Therefore‚ supplementation with 5-HTP will bypass the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase – which is the rate-limiting step in the synthesis of serotonin – and is a conversion that can be inhibited by a number of factors‚ including stress‚ insulin resistance‚ increasing age‚ and deficiencies of vitamin C‚ folate‚ and iron. 5-HTP is well absorbed when taken orally‚ with about 70 percent going into the bloodstream. Intestinal absorption of 5-HTP does not require the presence of a transport molecule‚ and its absorption is not affected by the presence of other amino acids; therefore‚ 5-HTP can be taken with meals without reducing its effectiveness. 5-HTP has been shown to have a beneficial impact on mood‚ sleep‚ carbohydrate cravings‚ and discomfort associated with fatigue. Numerous studies of individuals with negative mood status have shown significant positive response with 50-300 mg of 5-HTP daily.

To further facilitate serotonin production‚ Thorne's 5-HTP formula contains pyridoxal 5'-phosphate‚ the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin. 5-HTP is commercially produced by extraction from the seeds of the African plant‚ Griffonia simplicifolia.


These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

  • MFG # SA503
  • UPC # 693749503026
Official Website: https://www.thorne.com

Serving Size: Two Capsules
Servings Per Container: 45

Two Capsules Contain: / %DV

Vitamin B6
(as Pyridoxal 5'-Phosphate) 6.8 mg / 400%
5-Hydroxytryptophan 100 mg / *

*Daily Value (DV) not established.

Other Ingredients: Microcrystalline Cellulose‚ Hypromellose (derived from cellulose) capsule‚ Leucine‚ Silicon Dioxide.

Gluten Free.

Take 1-2 capsules three times daily or as recommended by your health-care practitioner.

TAMPER EVIDENT: Use only if bottle is sealed. Store tightly sealed in a cool‚ dry place.

WARNING: If pregnant or nursing‚ do not use this product.

  • Egg Free
  • Gluten Free
  • High Fructose Corn Syrup Free
  • Nut Free
  • Peanut Free

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If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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