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UltraMeal Medical Foods

Managing the Metabolic Syndrome Continuum

UltraMeal® medical foods are specifically formulated to nutritionally support patients with metabolic syndrome and associated CVD risk factors while promoting a healthier body composition.


UltraMeal PLUS 360° Medical Food Clinical Study.

In a 12-week, open-labeled, randomized, 2-arm study of 44 subjects fulfilling 3 or more metabolic syndrome criteria, the UltraMeal PLUS 36o° Medical Food Program was shown to more effectively address CVD risk factors than a low-glycemic-load (LGL) eating plan and exercise alone

Clinically Demonstrated Support for Metabolic Syndrome and CVD.

Clinical studies with each successive UltraMeal medical food formulation used in combination with a low-glycemic-load diet and simple exercise regimen continue to demonstrate success versus dietary changes and exercise alone

An Effective Lifestyle Therapy for Conditions Related to Metabolic Syndrome & CVD without Serious Adverse Effects
Because of the potential adverse events associated with conventional and "polypharmacy" approaches, leading health organizations recommend lifestyle intervention as the preferred treatment for the cluster of conditions related to metabolic syndrome and cardiovascular disease (CVD). That's where UltraMeal medical food programs make a noticeable difference.
The need for a safer approach
Patients with metabolic syndrome have multiple metabolic risk factors that include abdominal obesity, elevated triglycerides and/or LDL cholesterol, low HDL cholesterol, elevated blood pressure, insulin resistance, and a pro-inflammatory state (e.g., elevated C-reactive protein). The risk-to-benefit assessments of conventional approaches for managing insulin resistance, lipid metabolism, and blood pressure have led many national health experts to establish recommendations for lifestyle intervention (e.g., diet, exercise) before pharmaceutical or combination therapies are considered.
The need for a more effective lifestyle therapy approach
Some dietary plans may result in positive body mass index (BMI) changes without anticipated improvement in other objective markers of metabolic syndrome. That's because a loss of lean muscle tissue may be increasing the fat-to-lean body mass ratio, resulting in an unhealthy body composition. A growing body of research suggests that a Mediterranean-style diet—lower in calories and rich in nutrient-dense whole grains, legumes, and vegetables—may help fight conditions related to chronic inflammation, including metabolic syndrome. And incorporating targeted nutrition with an effective lifestyle intervention can produce even greater objective results than dietary changes and exercise alone.
Empowering patients to address the underlying pathologies
Only the UltraMeal Program offers a powerful combination of clinically demonstrated medical food support, simple exercise, and a science-based eating plan—a modified Mediterranean diet with a low¬glycemic-load to help balance blood sugar levels.' With the UltraMeal Program, which can be followed long term to both manage metabolic syndrome and reduce risk to more serious diseases, patients learn lifetime habits and see measurable results within weeks. But just as important are the results that they feel, such as increased energy and renewed commitment to taking care of their health.
UltraMeal PLUS 36o° and UltraMeal PLUS 36o° RICE are part of a select group of novel formulations that set a new standard of clinical certainty in natural products by demonstrating efficacy, bioavailability, and a high level of predicted safety.
The ExpresSyn Process is the most significant product development innovation in the history of nutraceuticals and combines cell proteomic research, safety evaluations, human ex vivo research, and human clinical research.

ExpresSyn Breakthrough: SKRMs
There are 540 known kinases—enzymes involved in key metabolic processes—that translate good food choices into signals of good health and poor food choices into signals of poor health. The remarkable discovery about kinase activity is that it has been correlated with insulin function and many other physiological activities.
Metagenics has scientifically tested SKRMs that specifically target insulin function—leading to the development of UltraMeal PLUS 36o° and UltraMeal PLUS 36o° RICE. These formulas are designed to modulate kinase signaling in favor of healthy insulin metabolism and glucose transport.

UltraMeal PLUS 360° Medical Food Clinical Study. In a 12-week, open-labeled, randomized, 2-arm study of 44 subjects fulfilling 3 or more metabolic syndrome criteria, the UltraMeal PLUS 36o° Medical Food Program was shown to more effectively address CVD risk factors than a low-glycemic-load (LGL) eating plan and exercise alone

Lipid Parameters
• Statistically greater reductions in fasting serum cholesterol & cholesterol/HDL ratio
• Statistically greater reductions in triglycerides & triglyceride/HDL ratio

HDL Level
• Statistically significant increase in HDL ("good") cholesterol

Apolipoprotein Parameters
• Persistent lowering effects on apoB and apoB/apoAi ratio
• ApoB may be a better indicator of CVD risk than total cholesterol or LDL
• ApoB/apoM. ratio is a newly recognized, increasingly significant indicator of CVD risk

UltraMeal PLUS 36o° Medical Food Program vs. LGL Food Plan & Exercise
Summary of Lab Value Changes


Arm 1:

UltraMeal® PLUS 36o° Ingredients with Mediterranean-Style LGL Food Plan & Exercise

% Change

Arm 2:

Mediterranean-Style LGL Food Plan & Exercise Only

% Change

Total Cholesterol (mg/dL)





Triglycerides (mg/dL)





HDL-C (mg/dL)





LDL-C (mg/dL)















Apok (g/L)





ApoB (a)










*Statistically significant difference from baseline.
Statistically significant difference between arms.


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