- MFG # 0295-200
- UPC # KM1125
Kirkman® offers 175 mg Trimethylglycine (TMG) in capsules with folinic acid and vitamin B-12. This is a hypoallergenic formulation‚ specially designed for individuals with special requirements and sensitivities.
Kirkman’s TMG is derived from beets‚ which is the commercially available source. TMG is dimethylglycine (DMG) with one more methyl group. The chemical structure of TMG is a glycine molecule holding onto three methyl groups. Like DMG‚ TMG is considered a "methyl donor" or “methyl bank." The additional methyl group makes TMG a more active methyl donor than DMG‚ which provides a benefit to some individuals. TMG can support the formation of methionine by methylating homocysteine. Some of this methionine eventually is converted into SAMe (S-adenosylmethionine)‚ which can help maintain healthy serotonin levels in the body‚ thus supporting mood and a feeling of well-being. As with DMG‚ TMG plus a coenzyme of riboflavin supplies methyl groups that attach to folic acid to form methylene tetrahydrofolate‚ an important component of many biochemical processes in the body including cellular perception and response.
Folic acid intake and levels in the body must be adequate for TMG to work biochemically. To be active in the body‚ folic acid needs to be reduced twice by folate reductase enzymes‚ then converted to tetrahydrofolate‚ after which a methyl group is added to the tetrahydrofolate. In some individuals‚ the use of natural folinic acid may be more beneficial than folic acid‚ because folinic acid already has attached four hydrogen atoms and one methyl group‚ thereby shortcutting the complicated biochemical processes that assist purine and nucleotide synthesis‚ which are so important in cell perception and response. For that reason‚ some doctors are recommending TMG with folinic acid instead of the folic acid form of folate.
Because folic acid can sometimes mask a vitamin B-12 deficiency‚ vitamin B-12 has also been included in this formulation. Furthermore‚ it is known that vitamin B-12 works synergistically with folic acid. The most active form of vitamin B-12 in folate chemistry is methylcobalamin‚ and Kirkman® utilizes this form of B-12 in this product‚ which may assist methionine metabolism‚ methylation‚ and folate chemistry.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 Capsule
Amount Per Serving / % DV*
Folinic Acid (calcium folinate) 200mcg / 50%
Vitamin B-12 (methylcobalamin) 6mcg / 100%
Trimethylglycine (TMG) 175mg / **
*Percent Daily Values are based on a 2‚000 calorie diet.
**Daily Value not established.
Trimethylglycine‚ Microcrystalline cellulose‚ magnesium stearate (vegetable)‚ mannitol‚ silicon dioxide‚ vitamin B-12‚ calcium folinate‚ plant cellulose capsule.
Casein‚ gluten‚ soy‚ yeast‚ milk‚ sucrose‚ preservatives‚ flavorings‚ colorings‚ gelatin‚ egg‚ peanuts‚ tree nuts or fish.
1-4 capsules daily or as directed by a physician.
Store in a cool dry place.
Keep out of the reach of children.
Allergy / Dietary Needs
- Casein Free
- Fungicide Free
- Gluten Free
- GMP Certification
- Herbicide Free
- Soy Free
- Yeast Free
- Mold Free
- Milk Free
- Corn Free
- Tree Nuts Free
- Peanut Free
- Fish Free
- Starch Free
- Sugar Free
- Wheat Free
- Preservative Free