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Science-based nutrition Dietary supplement Superior uptake, bioavailability and cell retention compared to other forms of vitamin C
PureWay-C® Sustained Release Vitamin C is a unique form of the essential nutrient vitamin C that contains vitamin C lipid metabolites. In fact, it is the most advanced form of vitamin C available. PureWay-C® has been studied in comparison to several other well-known forms of vitamin C.
Laboratory studies show that PureWay-C® has superior uptake, bioavailability and retention in cells, as well as more potent free radical scavenging capabilities than other forms of vitamin C, making it the preferred supplemental form of vitamin C on the market today. Because of its increased bioavailability, PureWay-C® has the potential to more potently support healthy neuron function and enhanced immune system activity as compared to other forms of vitamin C. PureWay-C® is all-natural, GMO-free and allergen-free.
Delivers Effective Antioxidant and Free Radical Scavenging Activity to Decrease Markers of Oxidative Stress
The PureWay-C® vitamin C-lipid metabolite formulation has potent antioxidant and free radical scavenging capabilities based on ORAC and DPPH assays, two methods commonly used to evaluate antioxidant capacities. PureWay-C® reached 93% scavenging capability using the DPPH assay, indicative of an excellent free radical scavenger. PureWay-C® has 1343 units of antioxidant activity per gram based on ORAC analysis (ORAC values are in ìM Trolox® Equivalents/gram of substance), showing stronger antioxidant activity on a gram basis than some other common natural sources of antioxidants such as green and black teas (235-1526 ORAC units), cinnamon (1243), and broccoli (65.8-121.6).
In order for vitamin C to exert its antioxidant benefits, it must be able to get inside cells. PureWay-C® was tested for its ability to be taken up and retained in the cell, and for the rate at which it is able to do so. Compared to ascorbic acid, the most common form of vitamin C, PureWay-C® showed a 233% increase in cellular uptake into human T-lymphocytes at both 30 and 45 minutes. This absorption level was a 122% improvement over the next best form of vitamin C, calcium ascorbate-calcium threonate-dehydroascorbate. The absorbed levels peaked at approximately two hours with the cellular level of PureWay-C® at 50 nmol / mg.
In order to assess absorption in humans, PureWay-C® serum levels were measured in healthy volunteers after oral supplementation. Forty volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of 1000 mg of either ascorbic acid, calcium ascorbate, PureWay-C®, or calcium ascorbate-calcium threonate-dehydroascorbate. Blood samples were collected immediately prior to the oral dose administration and at various times after ingestion. Serum vitamin C levels were measured, and PureWay-C® supplementation led to the highest absolute serum vitamin C levels when compared to the other forms of vitamin C. At two hours, PureWay-C® levels were statistically significantly higher than ascorbic acid and calcium ascorbate. At 24 hours post treatment, PureWay-C® maintained the highest serum levels of vitamin C.
Supports the Body’s Immune System
Excessive, chronic, or unbalanced immune activation is associated with a variety of health problems. High levels of certain proteins in the blood serve as indicators of this unhealthy condition. Levels of vitamin C in the blood have been found to be inversely associated with these protein markers of unbalanced immune activation. Recent research has attributed much of the beneficial immune-related effects of vitamin C supplementation to the reduction of circulating levels of these markers.
To test the effects of vitamin C on levels of these markers in humans, forty volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of 1000 mg of either ascorbic acid, calcium ascorbate, PureWay-C®, or calcium ascorbate-calcium threonate-dehydroascorbate. Blood samples were collected immediately prior to the oral dose administration and at various times after ingestion. Plasma levels of two markers of unbalanced immune activation were measured by enzyme linked immunosorbent assay (ELISA). Oral supplementation with PureWay-C® led to greater reductions in plasma levels of these markers compared to the other vitamin C formulations. Overall, PureWay-C® supplementation resulted in greater and more beneficial effects than what was observed with the other forms of vitamin C.3
Laboratory testing also indicates PureWay-C® has a greater protective effect on immune cells that have been exposed to toxins and pesticides.* PureWay-C® is more active and effective than ascorbic acid, calcium ascorbate and other popular forms of vitamin C in reducing hyperactivity of white blood cells and inflammatory damage caused by substances that are foreign to the body. Human T-lymphocytes are white blood cells that aggregate or clump together when exposed in the laboratory to toxins such as the common pesticide bifenthrin or the toxin phytohemagglutinin (PHA). These immune cells were treated in vitro with bifenthrin and PHA, and then either given no further treatments or treated further with PureWay-C® or other popular ascorbate brands. The cells were then incubated and the number of cells per aggregate was determined. PureWay-C® reduced PHA-induced T-cell aggregation, a marker of inflammatory hyperactivation, more than other popular forms of vitamin C. When these immune cells were treated with the pesticide bifenthrin, along with various formulations of vitamin C, all of the vitamin C formulations reduced the pesticide-mediated aggregation. However, the effect of PureWay-C® on inhibiting the aggregation was at least double the effect of the next best vitamin C formulation.
Various citrus bioflavonoids also possess a wide range of immune and inflammation- related therapeutic properties. Immune and inflammation responses are controlled by enzymes and cytokines produced in the body such as TNF-alpha, a pro-inflammatory cytokine. Citrus bioflavonoids can inhibit these enzymes and cytokines to decrease inflammatory responses in vitro. In vitro studies also indicate how bioflavonoids modulate inflammation through a number of other mechanisms, such as inhibition of gene expression in the cells lining blood and lymph vessels. In these ways, bioflavonoids may support overall immune health and wellness.
Supports a Healthy Cardiovascular System
Most prospective studies assessing vitamin C intake in large numbers of people who are followed over time indicate that the highest intakes of vitamin C are associated with enhanced cardiovascular benefits. In addition, some large studies in healthy individuals who take vitamin C supplements suggest that vitamin C supplements support normal heart function. The Nurses’ Health Study of more than 85,000 women followed for over 16 years found vitamin C intakes of more than 359 mg per day from diet plus supplements or from supplements alone were associated with a 27-28% reduction in cardiovascular risk factors. In a recent review of studies in which more than 290,000 healthy adults were followed for an average of 10 years, those who took more than 700 mg per day of supplemental vitamin C had a substantially better cardiovascular profile than those who did not take vitamin C supplements.
One of the ways vitamin C may enhance cardiovascular health is by supporting levels of good cholesterol (HDL) that are already within the normal range. Researchers from the National Institute on Aging and the USDA investigated the effect of vitamin C intake on lipid metabolism. After adjustment for age, sex, obesity, and smoking, they found that in healthy adults with adequate vitamin C intake there was a significant positive association between high levels of plasma vitamin C and healthy lipid ratios. The research suggested that higher concentrations of vitamin C in the blood, the result of taking up to two to three times the RDA, are associated with improved cardiovascular health.
Epidemiological and animal studies suggest that citrus bioflavonoids also support healthy cardiovascular function and circulation. An analysis of the flavonoid intake of 34,489 postmenopausal women in the sixteen-year Iowa Women's Health Study found significant positive correlations between flavonone and flavone intake and cardiovascular function. These two categories of flavonoids, flavonones and flavones, are the primary flavonoids found in citrus fruit. Hypothesized mechanisms by which flavonoids may have cardioprotective effects include antioxidant protection of lipid molecules, anti-inflammatory action, improvement in endothelial function, and enhancement of circulation.
Protects the Body’s Nervous System
Vitamin C is thought to protect the nervous system from degeneration. In order for nerve cells to survive, the body secretes a critical protein called nerve growth factor (NGF). In the laboratory, vitamin C formulations enhance the NGF-mediated growth of nerve cells. In vitro research indicates that compared to other forms of vitamin C, PureWay-C® is more beneficial to the nervous system. Nerve cells were treated with 100 ng/ml of NGF, and incubated for a 24-hour period. These cells then received either no further treatment, or treatment with 0.5 ìM of ascorbic acid, calcium ascorbate, PureWay-C® or other ascorbate brands. After these treatments, the cells were incubated over another 24-hour period during which the formation of developing nerve cells was assessed at hours 1, 3, 6, 9, 12 and 24. Compared with the other forms of vitamin C, PureWay-C® significantly increased the formation of developing nerve cells.
Citrus bioflavonoids have also demonstrated neuroprotective effects in laboratory and animal models. Hesperidin, for instance, has the ability to cross the blood brain barrier and act on the central nervous system. Hesperidin and related citrus bioflavonoids protect nerve cells against oxidative damage in vitro. Even at physiological concentrations, these flavonoids significantly protected cells of the nervous system from hydrogen peroxide-induced oxidative damage. Hydrogen peroxide is formed in the brain under certain conditions, and quickly converts to highly toxic hydroxy radicals that damage nerve cells.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 tablet Servings per container: 60
Amount per serving %DV
Vitamin C 500 mg 833% (as PureWay-C® and ascorbyl palmitate) ------------------------------------------------------------------------------------------ Citrus bioflavonoids 50 mg † ------------------------------------------------------------------------------------------ † Daily Value not established.
Other ingredients: Hydroxypropyl methylcellulose, vegetable fatty acids, magnesium stearate (vegetable source) and silicon dioxide.
Contains nothing other than listed ingredients.
Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives.
For continuous 24 hour Vitamin C coverage, take one tablet every 12 hours.
Consult a healthcare professional before use.
PureWay-C Sustained Release Vitamin C 60 Tablets
4.5 Stars based on 4 Review(s)
Coral Gables, FL
I would recommend this item to a friend.
Vitamin c is good
July 24, 2013
PureWay-C Sustained Release Vitamin C is necessary especially in times of stress, so I take this when I start to feel sick or tired and it works. Perks me right up.
Kansas City, MO
I would recommend this item to a friend.
great vitamin c
April 21, 2013
PureWay-C Sustained Release Vitamin C is absorbed better than other varieties, and I can tell because I was able to get over an infection more quickly.
I would recommend this item to a friend.
March 9, 2013
I have found that Vit C and Zinc lessen my allergies
I would recommend this item to a friend.
love the 24 release!!
December 5, 2012
i have been useing these for 6 months and i do see that it helps.
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Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).