Domestic orders placed by 5 PM Eastern Time will be packed and shipped the
same day, pending verification of billing information and the shipping
Orders containing refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
If an item on your order is on backorder we will notify you by email
and we will ship what we have in stock, the backordered item (s) will be
shipped as soon as it is back in stock (usually within 1 week or less)
Excludes all orders placed during weekends and on major US holidays(Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day)
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Order before 5 p.m. EST and this item will ship out today. Except during weekends and holidays.
We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
• Citrulline‚ a non-essential amino acid synthesized in the intestinal tract from Glutamine‚ converts to Arginine in a biochemical process involving Aspartic Acid and two necessary enzymes‚ Ornithine Transcarbamoylase and Argininosuccinate Synthetase. As a precursor to Arginine‚ it has a sparing effect on Arginine enabling an increase in Nitric Oxide production. Nitric Oxide (NO) is very important for endothelial support and cardiovascular health. Citrulline increases energy and stimulates the immune system‚ as well. • Citrulline is also an essential component of the Urea Cycle‚ and functions along with Ornithine and Arginine to convert ammonia into Urea. High ammonia levels are extremely toxic and can cause liver damage and neurological impairment. Supplementation with Citrulline has been very beneficial in a genetic disorder called Ornithine Transcarbamoylase (OTC) Deficiency.
CITRULLINE AND CARDIOVASCULAR HEALTH Citrulline is a precursor to Arginine‚ which has been shown to increase Nitric Oxide. Since up to 80% of Arginine is utilized in the liver and kidneys‚ only 20 % is available for cardiovascular support. Supplementing with Citrulline produces a sparing effect allowing for additional Arginine production intracellularly for cardiovascular function. Nitric Oxide (NO)‚ the endothelial relaxing factor (EDRF)‚ is a small molecule made from Arginine. It plays an essential role in the regulation of vascular homeostasis‚ modulates cardiac contractility‚ regulates vascular tone‚ and helps in preventing vessel injury and Atherosclerosis. Oxidative stress (free radicals damage) creates injury to endothelial cells. Citrulline converts to Arginine in the vascular cells‚ and thus increases Nitric Oxide production‚ which can help to restore endothelial cell function. The role of Nitric Oxide and Arginine supplementation‚ as well as the role of Citrulline in endothelial function has been well-documented in medical studies. Dr. S. Gross (Cornell U. Med. College) in his publication in the J. Biol. Chem.‚ 1997 suggests the ratio of 3 Arginine to 1 Citrulline for Nitric Oxide production.
• Those with active Herpes who need cardiovascular support should reverse the Citrulline/Arginine ratio to 3 Citrulline to 1 Arginine‚ since Arginine can stimulate the Herpes‚ and similar viruses. This ratio can help increase Arginine intracellularly. Lysine supplementation may also be advisable in some cases.
ORNITHINE TRANSCAR BAMOYLASE (OTC) DEFICIENCY This is a serious genetic Urea Cycle disorder effecting an estimated 1 in 20‚000 births. Ornithine ranscarbamoylase is the second enzyme in the Urea Cycle and is necessary to produce Citrulline. A deficiency of this enzyme Pauses a lack of Citrulline‚ thus the Urea Cycle cannot function properly and the result is hyperammonemia. It has been linked to SIDS deaths in newborns‚ and Reye's syndrome in children‚ since it is often undiagnosed. Symptoms of the neonatal onset disorder may appear in first 24 hours of life with vomiting and lethargy‚ followed by neonatal seizures and coma. This disorder often presents in males in the neonatal period‚ although partial enzyme deficiencies also affect both males and females in childhood and adulthood. This late onset form of the disorder may present In childhood with recurrent symptoms including lethargy‚ migraine-like headaches‚ persistent vomiting‚ dehydration‚ hyperactivity‚ bouts of screaming‚ acute taxia‚ retardation and coma. There are cases of female carriers of this disorder developing symptoms as adults as well. If untreated‚ it is 100% fatal‚ and there is no known cure. Limiting dietary protein‚ special formulas and Citrulline supplementation are advised to increase Urea Cycle function and reduce ammonia.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Ingredients per capsule:
Pure L-Citrulline 600 mg.
Take 1-3 capsules three times a day‚ or as needed.
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Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).