- MFG # 2812F
- UPC # NW1335
LV Renew boasts a powerful combination of milk thistle (80% silymarin) with synergistic nutrients known for their ability to support liver function. N-acetyl cysteine raises glutathione‚ the body’s strongest antioxidant‚ the majority of which functions in the liver. Other ingredients‚ such as cordyceps sinensis‚ dandelion‚ burdock and green tea also exhibit antioxidant and other beneficial properties that contribute to the strength of the formula.
The liver is a very resilient and regenerative organ‚ however there are many things that interfere with the health of this organ. Fat accumulation in the liver can result in sustained injury to liver cells‚ leading to the accumulation of collagen that starts a fibrotic cascade. Fat accumulation also sensitizes the liver to injury from a variety of causes and can impair the regenerative capacity of the liver. An additional stressor is sometimes reffered to as a "second hit" in a paradigm that identifies the accumulation of fat as the "first hit". Possible candidates for the second hit include increased oxidative stress‚ lipid peroxidation and release of toxins. A proactive nutrient approach to support the liver involves improving antioxidant status‚ fat metabolism‚ and detoxification to set the stage for a healthy liver environment.
Milk Thistle (Silybum marianum) is a flowering herb native to the Mediterranean region. It has been used for thousands of years for many things‚ but historically it is utilized mostly for the support of liver function. Silymarin is a flavonolignan complex isolated from milk thistle (which also contains "silybin") that has been called "cytoprotective" (cell-protectuve)‚ "immunostimulatory"‚ "antioxidant"‚ and "hepatoprotective" (liver protective) by researchers.
It is believed that silymarin exerts some of its effects through inhibition of free radicals and influence on inflammation. Scientists set out to assess liver function tests of 77 gas refinery workers chronically exposed to hydrogewn sulfide gas before and after administration of silymarin (140mg‚ three times per day for 1 month). A significant reduction of liver enzymes (blood AST‚ ALT and ALP) was observed after 30 days of consumption of silymarin.
Silibinin has been described as the most active component of the silymarin complex of flavonoids contained in milk thistle. According to Kostek et al. (2012)‚ its mechanism of action is complex and highly beneficial for liver cells‚ blocking the penetration of various toxins into the hepatocytes. It decreases oxidative free radicals by increasing the activity of the enzymes superoxide dismutase and glutathione peroxidase‚ as well as by increasing the concentration of glutathione (the body's well known and powerful antioxidant found mostly in liver). Silibinin strengthens and stabilizes the cell membranes‚ inhibits the synthesis of prostaglandins associated with the lipid peroxidation and "promotes regeneration of liver" through the stimulation of protein synthesis and effect on the production of new hepatocytes.
"Clinical trials conducted in this respect are very encouraging. The other beneficial application of silibinin is in therapy of the alcoholic liver cirrhosis. The evidence shows that the use of silymarin leads to a significant reduction in liver-related mortality and even reduction in the number of patients with encephalopathy in the course of the disease. Application of silibinin goes beyond liver disease. What is interesting is the fact that this substance of herbal origin occurring in the environment is so strong‚ favorable‚ beneficial and multidirectional"
Blood Sugar: Milk thistle was one of the nutraceuticals determined to "be the most beneficial" when it comes to supporting glucose control.
Nerve Health: Researchers claimed that "Our data demonstrate that milk thistle extract can promote neuronal differentiation and survival‚ suggesting potential benefits of chemicals in this plant on the nervous system".
Cordyceps Sinensis has been used widely in traditional Chinese Medicine (TCM) for centuries. WebMD describes cordyceps as a tonic and an adaptogen used to strengthen the immune system‚ incease energy‚ and improve liver function (WebMD.com cordyceps overview). Modern applications for cordyceps include muscle/athletic performance (increases production of ATP)‚ brain‚ heart‚ lung and mitochondria support‚ heavy metal detoxification‚ and improving the integrity of the HPA (Hypothalamus/pituitary) axis‚ thus calming the nervouse system and supporting restful sleep. It possesses antioxidant properties‚ and is known for its ability to help kidney function.
In a comprehensive two part revire series that covered preclinical in vitro and in vivo studies‚ and open-label and double-blinded clinical trails on the respiratory‚ renal‚ hepatic‚ cardiovascular‚ immunologic‚ and nervous systems‚ and its effects on the immune system‚ glucose metabolism‚ and inflammatory conditions‚ discussed effects on antisenscence‚ endocrine and sexual functions‚ atherosclerosis‚ hyperlipidemia‚ and free radicals) the reports were amazingly favorable in all categories.
A study from Int Immunopharmacol states that "many studies have shown that cordyceps sinensis has immunoregulatory activity in many disease models‚ but the underlying mechanism remains elusive".
Researchers tried to hypothesize about the underlying mechanisms with an experiment that altered T cell subsets in diabetes-prone mice. They discovered that the onset of diabetes was associated with an imbalance of regulatory T cells (cells that regulate and prevent overreactivity of the immune system) and aggressive T cells known as TH17 cells. When they administered cordyceps sinensis‚ it "resulted in reduction in the overall incidence of diabetes‚ and this was due to an increase in the ratio of Treg cells to Th17 in the spleen and pancreatic lymph nodes. Taken together‚ these data imply that cordyceps sinensis is able to modulate Treg to Th17 cell ratio in vivo..."
The major know effect of cordyceps is on the liver. In a rat study‚ researchers found that Cordyceps sinensis could "inhibit liver fibrogenesis derived from chronic liver injury‚ retard the development of cirrhosis‚ and notably ameliorate the liver function"; the possible mechanism involved inhibiting TGFbeta (1) expression‚ thereby preventing the deposition of procollagen I and III.
Nerve Health: Cordyceps was able to help when there was some impairment of the central nervous system; it reduced autonomic movements‚ and was able to increase the effects of sedatives.
N-Acetyl Cysteine is the main building block of the antioxidant glutathione. Since gastrointestinal absorption of the glutathione molecule is limited‚ administration of N-acetyl cysteine‚ as the rate limiting building block‚ is actually more effective at raising glutathione levels than administering glutathione because of N-acetyl cysteine is carried to the cells where glutathione is made internally. In fact‚ when someone suffers from acetaminophen (Tylenol) overdose‚ their symptoms are due to depletion of glutathione. However‚ the hospital standard of care is not to administer glutathione (due to poor absoroption)‚ the protocol is to administer N-acetyl cysteine‚ in order that the N-acetyl cysteine can be carried to the cells to make glutathione.
In a model of rats prone to liver injury‚ those given N-acetyl cysteine showed a decrease in congestion‚polymorphonuclear leukocytes‚ mononuclear leukocytes‚ vacuolar degeneration of hepatocytes‚ and hepatocellular necrosis. Researchers hypothesized that the antioxidant properties of N-acetyl cysteine were responsible for the favorable effect on liver health.
N-Acetyl-Cysteine and Nerve Health/Inflammation: N-actyl-cysteine demonstrated an effect on axonal sprouting in rats‚ leading scientists to speculate that there might be a therapeutic potential in the early treatment of traumatic spinal cord injury. Other researchers encourage "the use of N-actyl-cysteine for the experimental treatment of inflammatory pain in humans."
Green Tea Extract consists of several catechins‚ which include the well-known epigallocatechin gallate (EGCG). These catechins are rich in polyphenols and act as scavengers of reactive oxygen species (free radicals); their antioxidant activity is believed to function‚ in part‚ through modulation of transcriptional factors and enzyme activities. In PubMed‚ 168 studies pulled up under "green tea extract and liver" alone‚ attesting to the fact that green tea is a widely researched nutrient (especially in the animal model) for its "antioxidant and anti-inflammatory effects". In animal studies‚ green tea catechins were found to stimulate liver regeneration and attenuate liver dysfunction.
Green Tea reduces lipid peroxidation and increases the activities of antioxidant enzymes‚ such as catalase‚ glutathione peroxidase (GSH-Px) and glutatione reductase (GSH-Rd) in the liver. Reducing oxidative stress and increasing antioxidant enzymes may be mechanisms by which green tea is able to affect the deposition of collagen and fibrotic activity in the liver.
Green Tea and Nerve Health: Exogenously administered nerve growth factor (NGF) repairs injured axons‚ but it does not cross the blood-brain barrier. Therefore‚ scientists believe that agents with the ability to affect andogenous NGF would be of great utility for neurological injuries. An interesting study reporting that green tea polyphenols potentiated NGF demonstrated that the polyphenols‚ not one in particular‚ all "synergistically promoted this action". This report suggested that the polyphenols of green tea extract in its entirety (not fractionated into a specific catechin) was more effective than fractionated polyphenols (separated into specific catechins such as EGCG).
Dandelion has a reputation for liver support and action as a mild diuretic. Mechanisms may include the effect of dandelion root on fibrotic activity‚ possibly mediated by "the inactivation of hepatic stellate cells and enhancement of hepatic regenerative capabilities"‚ leading scientists to believe that there is enough scientific evidence to substantiate the traditional use of dandelion root in hepatic health.
It's believed that excessive oxidative stress contributes to the development of atherosclerosis-linked metabolic syndrome. According to one study‚ dandelion root cant "protect against oxidative stress linked atherosclerosis and decrease the atherogenic index".
Dandelion has shown an effect on immune parameters‚ including cytokines and interleukins‚ being cited as improving "fatigue-related indicators and immunological parameters".
Dandelion and Nerve Health: In a study reporting beneficial effects of a diet with added dandelion on lead toxicity (on rats) showed that the antioxidant property of dandelion was thought to be responsible for preventing absorption of lead into the brain and related damages.
Burdock Root‚ a perennial herb‚ has been cultivated for a long time as a popular vegetable. Burdock root improved activity of superoxide dismutase (antioxidant enzyme)‚ lowered MDA (sign of lipid peroxidation)and dramatically reduced lipofuscin (a wear and tear pigment associated with aging) in rats.
Burdock also surpasses the SGOT and SGPT elevations (liver enzymes) induced by toxic assault and alleviated the severity of liver damage based on histopathological observations in a similar study. Mechanisms of action included reversing the decrease in glutathione and P-450 normally induced by the toxic assault. The antioxidative effect was believed responsible for the beneficial effects of liver cells.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 Tablet
Amount Per Serving / % DV
Proprietary Blend 700mg / *
Milk Thistle Extract (80% silymarin)‚ Cordyceps Sinensis (8% cordyceptic acid)‚ Green Tea Extract (leaf)‚ N-Acetyl Cysteine‚ Dandelion (root)‚ Burdock (root).
*Daily Value (DV) not established.
Other Ingredients: Microcrystalline cellulose‚ vegetable stearine‚ stearic acid‚ magnesium stearate.
Take 1 tablet daily or as directed.
Milk thistle is generally very well tolerated. It may lower blood sugar levels. This is normally a good thing‚ but use caution with diabetes‚ hypoglycemia or drugs affecting blood sugar. Burdock may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family (eg. Ragweed). This product contains natural blood thinners and should not be combined with blood thinning drugs. Not recommended in pregnancy/lactation.
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