Domestic orders placed by 5 PM Eastern Time will be packed and shipped the
same day, pending verification of billing information and the shipping
Orders containing refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
If an item on your order is on backorder we will notify you by email
and we will ship what we have in stock, the backordered item (s) will be
shipped as soon as it is back in stock (usually within 1 week or less)
Excludes all orders placed during weekends and on major US holidays(Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day)
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Order before 5 p.m. EST and this item will ship out today. Except during weekends and holidays.
We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
Joint/Connective Tissue Function Stem Cell Support
A Dietary Supplement
Joint, Tendon, Ligament II is a unique formula designed to support healthy stem cell function that can contribute to healthy joints and tissues.† Specific nutrients, such as Vitamin C and Pterostilbene have been shown to support normal mesenchymal cell growth, migration and proliferation. † The combination of Lcarnosine, vitamin D3, green tea, and blueberry have been studied for their ability to influence stem cell activity.†
Dr. Martin Gallagher, M.D., D.C. has developed the Joint, Tendon, Ligament formulas to use for musculoskeletal support and in conjunction with regenerative therapies, such as prolotherapy, PRP, acupuncture, and manipulation. Joint, Tendon, Ligament I and II can be taken together for optimal results.
FUNCTIONS Maintaining optimal tissue and joint health is dependent in part upon the activation of healthy, endogenous stem cells, particularly mesenchymal cells. Mesenchymal stem cells (MSCs) differentiate into multiple cell types and have demonstrated the ability to migrate through the peripheral circulation to the site where they may be most needed. Stem cells are found in many organs, including bone marrow, peripheral blood, umbilical cord, spleen and brain. Research is evolving to discover how to optimize endogenous stem cell production and health in adults to promote self-healing.
Specific nutrients may help contribute to stem cell stimulation and migration to support tissue, tendon, and ligament health. Pterostilbene, a methylated resveratrol, supports healthy apoptosis, which has been suggested to be an important factor in influencing targeted migration of stem cells from blood to tissues.†
Pterostilbene can also support tissue health by down regulating iNOS and COX-2 gene expression.† pTeroPure™ pterostilbene is a nature identical form of trans-pterostilbene, a stilbene found in certain berries and considered a methylated form of resveratrol. Pterostilbene has greater lipophilicity, a longer half-life and a higher potential for cellular uptake than resveratrol.
Researchers have reported that vitamin D3, L-carnosine, blueberry and green tea produce a synergistic effect to promote proliferation of human stem cells, also called hematopoietic progenitors.† In vitro studies demonstrate that vitamin D3 has a dramatic effect on stimulating the proliferation of progenitor cells.
Blueberries, known for their significant antioxidant activity have demonstrated the ability to modulate cell signaling activity, while green tea active compounds may promote normal cellular growth.†
Folate, supplied as the bioavailable methylfolate, and vitamin B-12 as methylcobalamin play important roles in erythropoiesis (red blood cell formation), and low levels of these nutrients can result in less than optimal cellular health. Metafolin® is a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF) and is the naturally occurring, predominant form of folate commonly found in cells.
Vitamin C (ascorbic acid) has been shown to positively modulate mesenchymal stem cell proliferation and motility via hepatocyte growth factor (HGF). Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of epithelial origin. Additionally, recent in vitro research has shown that vitamin C was able to induce telomerase activity in periodontal ligament stem cells and enhance the expression of type I collagen, fibronectin, and other markers of tissue health.
Vitamin K together with vitamin D has been shown to increase osteoblast markers in human MSCs isolated from fracture sites. These nutrients may therefore play an important role in support of bone and tissue health.†
INDICATIONS Joint, Tendon, Ligament II is indicated for individuals that desire additional support of healthy tissues.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size 3 Vegetarian Capsules Servings Per Container 30
Amount Per Serving / %DV
Vitamin C (asAscorbicAcid)...........................1,000 mg / 1,667% Vitamin D-3.......................................................1,000 IU / 250% Vitamin K-2 (as menaquinone-7)........................45 mcg / 56% Folate (as L-methylfolate, Metafolin®)...............400 mcg / 100% Vitamin B-12 (methylcobalamin).......................500 mcg / 8,333% L-Carnosine........................................................250 mg / * Green Tea leaf Extract........................................250 mg / * (Camellia sinensis)(standardized to 98% polyphenols, 80% catechins, 45% EGCG, decaffeinated) Wild Blueberry fruit Extract.................................250 mg /* (Vaccinium angustifolium) (standardized to 4% polyphenols) Pterostilbene.........................................................50 mg / * (methylated resveratrol, pTeroPure™)
*Daily Value not established.
This product contains NO yeast, wheat, gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.
Allergy Information - Product Details
No Artificial Colors
No Artificial Flavors
As a dietary supplement, adults take 3 capsules daily with a meal or as directed by a healthcare professional.
Warning:This product contains Vitamin K, which interferes with the prescription drug Coumadin (Warfarin). If taking this drug, consult your physician prior to use.
For optimal storage conditions, store in a cool, dry place. (59˚-77˚F/15˚-25˚C) (35-65% relative humidity) Tamper resistant package, do not use if outer seal is missing.
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Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).