Homocystrol® +TMG 90 Vegetarian Capsules

  • Item Number: DL1461
  • Serving Size: 3 Vegetarian Capsules
  • Servings per Container: 30
  • Amount per Container: 90 Vegetarian Capsules
  • Price per Serving: $1.00
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  • Availability: 6 In Stock
  • This item will ship on Monday before 5PM EST.

  • MFG # 201329-90X
  • UPC # 310539038109
  • Cardiovascular Health

    Homocystrol™ + TMG‚ provided by Douglas Laboratories‚ contains significant amounts of activated B vitamins‚ trimethylglycine (betaine) and choline needed for proper metabolism of homocysteine‚ and the support of metabolic synthetic processes requiring methyl donors.

    Revised Formulation
    Homocystrol™ + TMG now provides bioavailable forms of B vitamins. Methylcobalamin‚ methylfolate‚ pyridoxal-5-phosphate‚ and riboflavin-5-phosphate are the forms most readily used by the body and do not require conversion once consumed.

    Homocysteinemia‚ or elevated plasma homocysteine‚ is a major factor that can influence poor cardiovascular health. High plasma levels of homocysteine appear to have negative effects on the vasculature‚ impairing the functional abilities of endothelial and smooth muscle cells. Suboptimal intake of several B vitamins‚ renal
    failure‚ environment‚ diet‚ stress‚ and genetic defects in homocysteine metabolism can all contribute to abnormal homocysteine levels.

    Homocysteine is a sulfur containing amino acid that is created in the body from methionine‚ an essential amino acid derived solely from dietary intake. Methionine is metabolized into homocysteine via an intermediate‚ Sadenosylmethionine. Homocysteine can be metabolized to produce cysteine‚ a nonessential sulfur-containing amino acid‚ or it can be remethylated to methionine. Whether the body needs cysteine or methionine will dictate which path homocysteine metabolism will take.

    Production of cysteine from homocysteine requires two specific enzymes for which vitamin B-6 is an essential coenzyme. Without adequate vitamin B-6‚ homocysteine cannot be metabolized into cysteine. The body can also metabolize homocysteine by remethylating it to methionine. The primary route by which homocysteine is remethylated to methionine requires folate in the form of methyltetrahydrofolate as a methyl donor and vitamin B-12 (methylcobalamin) as a coenzyme. Methyltetrahydrofolate‚ or L-methylfolate‚ is synthesized in the body from dietary folic acid. However‚ L-methylfolate can be used directly by the body‚ without the need for folic acid conversion via the enzyme 5‚10-methylenetetrahydrofolate reductase (MTHFR). In certain populations‚ the body’s ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences.

    B vitamins‚ in particular folate‚ methylcobalamin‚ and vitamin B-6 are necessary for the body to metabolize homocysteine. A deficiency or suboptimal levels of any of these essential vitamins may cause plasma homocysteine levels to rise. Dietary surveys and epidemiological studies indicate that suboptimal levels of folate‚ vitamin B-12‚ and vitamin B-6 are common in many population groups. Elderly individuals‚ smokers‚ alcoholics‚ and medications users‚ including estrogens and popular medications for cholesterol and blood glucose control‚ are at risk for subclinical deficiencies of one or more of these B vitamins.

    TMG‚ trimethylglycine‚ also known as betaine anhydrous‚ acts as a methyl donor in the methionine/homocysteine cycle. One route of homocysteine metabolism is by methylation to form methionine‚ using a methyl group from methylcobalamin or from trimethylglycine. Methionine is then converted to Sadenosylmethione (SAMe). Trimethylglycine is absorbed rapidly and has a high volume of distribution due to
    extensive distribution to tissues‚ including the kidneys and liver. When taken orally‚ trimethylglycine can support normal homocysteine levels.† Improvement in plasma homocysteine may be seen within a week‚ and steady state could be reached within a month.

    Choline‚ also considered a B vitamin‚ can be oxidized to betaine which serves as a methyl donor to convert homocysteine to methionine. Dietary intake of choline might also support healthy homocysteine level.† The effect of dietary choline intake may be greatest on those with lower folate levels.

    These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Official Website: http://www.douglaslabs.com

Serving Size 3 Vegetarian Capsules
Servings Per Container 30

Riboflavin.............................................50 mg
(as Riboflavin-5-Phosphate)
Vitamin B-6 .........................................50 mg
(as Pyridoxal-5-Phosphate)
Folate ..............................................800 mcg
(as L-methylfolate‚ Metafolin®)
Vitamin B-12 ................................1‚000 mcg
Magnesium……................................. 50 mg
(as Magnesium Chelate)
Trimethylglycine…..........................1‚000 mg
Choline .............................................150 mg
(as Choline Bitartrate)

Other ingredients: Hydroxypropyl methylcellulose (capsule)‚ cellulose‚ vegetable stearate‚ and silica.

This product contains NO yeast‚ wheat‚ gluten‚ soy protein‚ milk/dairy‚ corn‚ sodium‚ sugar‚ starch‚ artificial coloring‚ preservatives or flavoring.

Metafolin® is a registered trademark of Merck KGaA‚ Darmstadt‚ Germany.

Adults take 3 capsules daily‚ in divided doses‚ or as directed by your healthcare professional.

For optimal storage conditions‚ store in a cool‚ dry place. (59˚-77˚F/15˚-25˚C) (35-65% relative humidity) Tamper resistant package‚ do not use if outer seal is missing.

  • GMP Certification
  • Organic Product
  • Gluten Free
  • Soy Free
  • Corn Free
  • Dairy Free
  • Milk Free
  • Yeast Free
  • Artificial Color Free
  • Artificial Flavor Free
  • Vegetarian Product
  • Sodium Free
  • Starch Free
  • Sugar Free
  • Wheat Free
  • Made In The Usa
  • Artificial Preservative Free

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