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In its native India, coleus has been used in the ancient medical system of Ayurveda for centuries. Ayurvedic traditions recommend coleus to aid the health of the heart, respiratory system, and digestive tract, among other uses.
Coleus forskohlii is the only plant known to contain the diterpenoid forskolin. Forskolin activates adenylate cyclase, which in turn activates cyclic adenosine monophoshate (cAMP), an intracellular second messenger responsible for inducing the cellular response to hormonal activation. Because forskolin effectively activates cAMP, it has been used in numerous research studies to explore the mechanisms and effects of cAMP.
Within the body, hormones bind to extracellular membrane receptors on their target cells. Following hormone-receptor binding, adenylate cyclase is activated from the inner cellular membrane. Adenylate cyclase catalyzes the conversion of adenosine triphosphate (ATP) to cAMP. This conversion fosters the activation of cAMP-dependent enzymes. The cAMP-dependent enzymes in turn activate or inhibit the specific enzymes within the cell, thereby eliciting the response associated with the binding hormone. Catecholamines, adrenocorticotropic hormone, and vasopressin are among the many hormones that elicit action via the cAMP second messenger system.
Forskolin activates adenylate cyclase, thereby increasing cAMP levels without direct hormonal stimulation. By activating cAMP, forskolin can direct the activation of the many, diverse cAMP-activated enzymes.
Laboratory and clinical studies have documented several benefits of forskolin. Forskolin has cardiac inotropic properties in that it appears to help strengthen heart muscle contractability. Forskolin promotes vasodilation, thereby decreasing peripheral vascular resistance. Compounds in coleus including, but not limited to, forskolin, provide further benefit to the cardiovascular system by inhibiting platelet aggregating factor. Forskolin has also been shown to promote bronchodilation, in part by helping to relax airway smooth muscles and by inhibiting histamine and leukotriene release.
Other research studies suggest forskolin may stimulate lipolysis by increasing adipose cell cAMP levels. Forskolin may also stimulate the release of thyroid hormone and potentiate glucose-mediated insulin release.
Coleus Extract capsules may be a beneficial nutritional supplement for individuals who wish to obtain the natural properties of this standardized botanical extract.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Amount Per Serving
Coleus forskohlii ...250mg* Extract (root) (standardized to 10% forskohlin)
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Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).