Domestic orders placed by 5 PM Eastern Time will be packed and shipped the
same day, pending verification of billing information and the shipping
Orders containing refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
If an item on your order is on backorder we will notify you by email
and we will ship what we have in stock, the backordered item (s) will be
shipped as soon as it is back in stock (usually within 1 week or less)
Excludes all orders placed during weekends and on major US holidays(Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day)
Order status and tracking information is updated
1 business day or less after the order is placed . You can now get real-time
status on your PureFormulas order on your cellphone or online.
Track your order
Order before 5 p.m. EST and this item will ship out today. Except during weekends and holidays.
We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
Experimental calorie restriction often improves protein metabolism by the variable elimination of cross-linked protein products (AGEs).
The restriction of calorie intake has been shown to exert powerful anti-aging benefits in several animal species; and it may be effective in humans. The act of substantial and continuous calorie restriction (at least 30% reduction) is a monumental task for many individuals, with obvious problems of compliance. There are several proposed or documented effects of calorie restriction on body structures and functions, including: insulin sensitization, apoptosis regulation, decreased oxidative stress, stimulation of endogenous growth factors, enhanced tissue repair, anti-stress actions and modulation of protein metabolism. Experimental calorie restriction often improves protein metabolism by the variable elimination of cross-linked protein products (AGEs), as a consequence of down regulation of "chaperone molecules", with resulting increase in hepatic protein elimination. Calorie restriction has been associated with reductions in total blood cholesterol and blood markers of inflammation; it causes improvements in glucose tolerance (anti-diabetic effect).
These beneficial effects of calorie restriction have been observed most often in animal experiments (including primates), and they are the subject of contemporary research in humans. While many of these benefits of calorie restriction are related to reduction of adipose tissue mass, other complex factors operate. The concept of "calorie restriction mimetics" was proposed in the late 1990s and this resulted in several basic science experiments that have demonstrated the effects of calorie restriction in animals on promoting substantial extensions of lifespan in animals by effects on gene pathways. Several drugs, nutrients or botanicals have been proposed as agents that can mimic the effects of calorie restriction, in a variable manner.
A number of examples of calorie restriction mimetics have variable beneficial effects on glucose metabolism and they can modulate genes that are involved in mechanisms of aging, e.g. resveratrol and apoptosis regulation, the oxidized form of nicotinamide adenine dinucleotide in the activation of Sir2p and the restoration of gene activity (daf-2 and age-1) in nerve cells. Well-defined examples of calorie-restriction mimetics include: resveratrol, gymnema alkaloids, alpha lipoic acid, cinnamon (methylhydroxychalones), indoacetate, oxaloacetate, metformin and thiazolidinediones.
While calorie restriction mimetics may appear to focus on the issue of calorie restriction per se, it is clear that these agents match the potential correction of several hypotheses of aging (e.g. theories of free radical damage, protein cross linking, repair budgets, anti-inflammatory approaches, dysglycemia etc). In brief, calorie restriction mimetic factors are a unique class of agents that are biological response modifiers. The synergistic use of calorie restriction mimetic factors is a logical approach to attempt to retard tissue aging, and it has an evidence-based perspective. While it is naïve to think that there is a "magic bullet" approach to anti-aging2, the adjunctive use of remedies of natural origin as recuperative or anti-aging factors has an established basis in good scientific agreement.
Calorie Restriction Mimetics™contains a proprietary blend of substances that are classified in this new group of potential agents that may alter body structures and functions associated with aging.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Resveratrol (50% extract), L-Carnosine, Gymnema sylvestre (25% extract of gymnemosides), alpha lipoic aicd, cinnamon bark (15% extract as a source of methylhydroxychalones), N-Acetyl-L-Carnitine, grape seed extract (95% oligomeric proanthocyanidins, Vitis vinifera), ellagic acid (40% extract of pomegranate fruit, Punica granatum) green tea extract (95% polyphenols, Camellia sinensis), pine bark (85% extract, Pinus maritime), and avocado fruit (Persea Americana).
PureFormulas is your one-stop shop for health supplements, vitamins, minerals and other nutritional supplements. We carry thousands of products from a huge variety of prescreened manufacturers because our goal is to help you achieve optimal health, regardless of your age, lifestyle or location.
At PureFormulas, we hand pick every item in our inventory. We only work with the most reputable, trusted manufacturers of vitamins, minerals and nutritional supplements.
When you order from PureFormulas, you're getting access to our large inventory, the convenience of fast, free shipping, and the comfort of knowing your order is guaranteed authentic and fresh. Our dedicated team is here to make sure you have access to the best health supplements, vitamins and minerals and other nutritional supplements. Our friendly, efficient customer service is second-to-none, and we guarantee your satisfaction on every order you place through PureFormulas.
We invite you to browse our large selection of vitamins and minerals, nutritional supplements and other health supplements, and please contact us if you have any questions. We look forward to meeting your needs today!
Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).