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same day, pending verification of billing information and the shipping
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Order before 5 p.m. EST and this item will ship out today. Except during weekends and holidays.
We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
Calcium D-Glucarate™ supplies D-glucaric acid bound to calcium which serves as a bioavailable precursor to D-glucaro- ,1-4 lactone.
Calcium D-Glucarate, provided by Douglas Laboratories, is a natural supplement of D-glucaric acid bound to calcium.
Calcium D-Glucarate may be a useful dietary supplement for those who wish to supplement their diet with D-glucaric acid as a precursor to D-glucaro- 1, 4-lactone.
Calcium D-glucarate enhances the body’s natural defenses against environmental toxins and excess steroid hormones. Through the actions of its metabolite D-glucaro-1,4-lactone, calcium-d-glucarate indirectly favors glucuronidation, an important system that the body relies upon to deactivate and eliminate toxins and steroid hormones. Glucuronidation is a conjugation process through which potentially carcinogenic environmental toxins, such as polycyclic aromatic hydrocarbons and nitrosamines, and excess steroid hormones are neutralized.
During glucuronidation, the enzyme glucuronosyl transferase catalyzes the conjugation of free carcinogens and steroid hormones to glucuronic acid. The resulting glucuronide-bound toxins and hormones can then be safely excreted in bile and urine. The body also deconjugates glucuronide-bound end products. The release of glucuronide-bound substances is beneficial in some circumstances, for example, when the excretion of steroid hormones is undesirable. Yet, the deconjugation process, which works via the enzyme beta-glucuronidase, can result in the re-release of harmful toxins back into the body.
The benefits of calcium D-glucarate are realized indirectly through the action of its metabolite Dglucaro- 1,4-lactone, which inhibits the deconjugating enzyme beta-glucuronidase found in both blood and tissue. Inhibition of beta-glucuronidase causes a net increase in glucuronidation, and thereby enhances a primary detoxification pathway in the body. Animal studies have documented a decrease in B-glucuronidase activity in breast, liver, colon, skin, lung, and prostate tissue following oral administration of calcium D glucarate.
Once ingested, Calcium D-glucarate is converted to Dglucaric acid in the presence of gastric HCl. The body normally maintains an equilibrium between D-glucaric acid and its two metabolites, D-glucaro-1,4-lactone and D-glucaro-6,3-lactone. Calcium D-glucarate provides a slow-release source of D-glucaro-1,4-lactone. When taken directly, D-glucaro- 1,4-lactone is metabolized quite quickly and is excreted from the body usually within 1-2 hours of its administration. Calcium D-glucarate, however, is metabolized slowly, remaining in the body for 5 or more hours after ingestion. This results in maintenance of stable levels of D-glucaro-1,4-lactone for long periods of time. D-glucaric acid is produced endogenously in small amounts. It is also present in some fruits and vegetables, including oranges, apples, grapefruit, broccoli and other cruciferous vegetables.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Amount Per Serving
Calcium ...63mg / 6% DV (from 500 mg Calcium D-Glucarate)
Gelatin (capsule), cellulose, water and magnesium stearate
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We invite you to browse our large selection of vitamins and minerals, nutritional supplements and other health supplements, and please contact us if you have any questions. We look forward to meeting your needs today!
Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).