Best Benfotiamine 300 60 Veggie Caps

  •  
  •  
  •  
  •  
  •  
  • Brand: Doctors Best
  • Item Number: DRB1059
  • Serving Size: 1 Capsule
  • Servings per Container: 60
  • Amount per Container: 60 Capsules
  • Price per Serving: $0.24
  Free Shipping included for all US addresses and territories View Details
Regular Price: $26.99 $14.26
 
  • Availability: 27 In Stock
  • This item will ship today if ordered within 4 hr 7 min
 
  • MFG # DRB-00270
  • UPC # 753950002708
  • Benfotiamine (S-benzoylthiamine-O-monophosphate) is a synthetic derivative of thiamin‚ belonging to the family of compounds known as "allithiamines." Benfotiamine is fat-soluble and more bioavailable and physiologically active than thiamin. Benfotiamine raises the blood level of thiamin pyrophosphate (TPP)‚ the biologically active co-enzyme of thiamin‚ and stimulates transketolase‚ a cellular enzyme essential for maintenance of normal glucose metabolic pathways.

    Support against oxidative stress

    Benfotiamine displays direct antioxidant action in vitro‚ and preliminary research with human subjects suggests that this activity can be advantageous in helping to safeguard the integrity of human DNA by increasing the antioxidant capacity of plasma.8 In the laboratory‚ when human‚ rat‚ and porcine kidney cells were exposed to toxins that assault the integrity of DNA‚ benfotiamine was able to reduce oxidative stress under these circumstances. Benfotiamine‚ like vitamins C and E‚ can deter the activation of NF-kB (a DNA-binding factor known to be activated by oxidative stress-generated reactive oxygen species) for more balanced immune responses. Furthermore‚ recent in vitro results suggest that the beneficial antioxidant properties of benfotiamine could work against some forms of lipid peroxidation. An animal model suggests that during oxidative stress generated by excess glucose‚ benfotiamine has the capacity to reduce levels of superoxide and hydroxyl radicals in the heart. Similarly‚ an animal model of induced oxidative stress in the cerebral cortex (the outer most layer of the brain) suggests a beneficial antioxidant effect of benfotiamine.

    Supports blood levels of thiamin pyrophosphate (TTP)‚ the biologically active co–enzyme form of thiamin
    Helps maintain healthy glucose metabolism

    Benfotiamine increases blood and tissue levels of thiamin pyrophosphate (TPP)‚ the biologically active co-enzyme form of thiamin. TPP acts as a co-enzyme for three critical enzymes involved in glucose metabolism: 1) transketolase‚ 2) pyruvate dehydrogenase‚ and 3) a-ketoglutarate decarboxylase. The latter two enzymes are involved in utilizing glucose for fuel. Thus‚ TTP is vital to the cell’s energy supply.

    Stimulates transketolase‚ a cellular enzyme essential for maintenance of normal glucose metabolic pathways

    Superoxide‚ a type of free radical known as a reactive oxygen species (ROS)‚ is a highly toxic molecule produced by our immune system as part of our defense network; in this capacity‚ it is carefully controlled and works in our favor. However‚ superoxide is also a byproduct of cellular energy production and other vital processes such as the breakdown of nucleic acids (DNA & RNA) and ATP. It can be produced in quantities beyond our immediate capacity to neutralize‚ hindering another enzyme involved in the metabolism of glucose‚ GAPDH. This can lead to a build up of upstream glucose metabolites; in other words‚ the pathway can get “backed up.” Biological metabolic pathways can be thought of as similar to assembly (or disassembly) lines‚ where enzymes in the pathway are analogous to steps in the assembly or disassembly of a product. Blocking GAPDH essentially slows the metabolism of glucose‚ causing a build up of the metabolites being produced up to that point in the process. These glucose metabolites can be safely metabolized by transketolase. However‚ if transketolase activity is not optimal‚ some of these metabolites may be diverted to other biochemical pathways‚ including the production of advanced glycation end-products (AGEs). Benfotiamine can enhance transketolase activity by promoting tissue levels of TPP.

    Supports healthy aging
    Disrupts formation of Advanced Glycation End-Products (AGEs)
    Helps maintain healthy circulation

    This benfotiamine enhanced transketolase activity leads to metabolic pathways favoring less production of AGEs. AGEs are formed by a complex series of reactions between reducing sugars and amino acids on proteins‚ lipids‚ and nucleic acids. Diet is a major external source of AGEs‚ with about 10% of AGEs from food remaining in the body after ingestion. Bodily AGE levels are higher in smokers and individuals consuming AGE-rich diets. In food‚ AGEs are created by a non-enzymatic browning process called the Maillard reaction‚ which can contribute to desired colors‚ odors‚ and tastes (caramelized onions is one example of the reaction’s results). However‚ this reaction is not restricted to food; in 1981‚ researchers discovered that the Maillard reaction also takes place within the body‚19 and that it accelerates as we age (hence the term “AGE”). AGEs are especially a concern among long–lived proteins‚ such as serum albumin‚ lens crystalline‚ and collagen in the extracelluar matrix. Internal AGEs may also be formed within cells due to accumulation of super–reactive glucose metabolic intermediates‚ such as triosephosphates‚ affecting nearby proteins‚ lipids‚ and DNA.

    In a crossover study of 13 participants‚ a test meal with high AGE content was provided before and after 3 days of oral benfotiamine administration at a dose of 1‚050 mg. Measurements of endothelial function (behavior of cells lining the blood vessel walls) and oxidative stress were taken on both occasions. The high AGE meal significantly increased TBARS (an indicator of oxidative stress) and impaired circulation—yet these effects of the meal were negated by supplemental benfotiamine when compared to the baseline meal as measured prior to supplementation. Although this study was small and more research is needed‚ it implies that benfotiamine may help to maintain healthy post-meal circulation. In laboratory animals‚ benfotiamine has been demonstrated to decrease AGE production in the nerves‚ kidneys‚ and retina of the eyes. While these studies are suggestive of an ability of benfotiamine to reduce production of AGEs in humans‚ this has yet to be strongly demonstrated clinically.

    Helps maintain nervous system health

    Benfotiamine also has a history of nerve-related research‚ including a 3-week randomized‚ double-blinded‚ placebo-controlled pilot trial of 40 participants. In this short study‚ the group taking 400 mg benfotiamine daily had superior sensory function and other statistically significant outcome measures pertaining to nerve health. These findings are supported by results from other placebo-controlled trials in which benfotiamine was administered as tablets or capsules in doses ranging from 120 to 600 mg daily (higher doses showed the greatest benefit). In a mouse model‚ benfotiamine has been shown to support cognitive function.





    These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Official Website: http://www.drbvitamins.com

Serving Size: 1 capsules
Servings per container: 60 servings

Amount Per Serving %DV

Benfotiamine 300 mg †
------------------------------------------------------------------------
† Daily Value not established.

Other Ingredients: Modified cellulose (vegetarian capsule)‚ cellulose‚ silicon dioxide.

Contains nothing other than listed ingredients.

Does Not Contain: milk‚ egg‚ wheat‚ gluten‚ corn‚ soy‚ sugar‚ sweeteners‚ starch‚ salt‚ or preservatives.

Take 1 capsule daily‚ with or without food.

Benfotiamine has an excellent tolerability profile and can be taken for long periods without adverse effects.

  • Vegan Product
  • Vegetarian Product

Ratings & Reviews

Review This Item

Overall Rating for Best Benfotiamine 300 60 Veggie Caps

  •  
  •  
  •  
  •  
  •  
5 6 Based on 6 reviews

Displaying reviews 1-6 of 6

  • By
    from Garland

      5
      •  
      •  
      •  
      •  
      •  

    2/17/2014

    Great Product

    I love this product. It does help my digestion and my IBS. Still waiting to see some improvement with my diabetic neuropathy some help in inflation

    Pros

      Always fresh and well packaged. Great money savings

    Cons

      None

    I would recommend this item to a friend.

     
  • By
    from pajones777@yahoo.com

      5
      •  
      •  
      •  
      •  
      •  

    10/29/2013

    Diabetic Neuropathy

    Used for over four years to protect the lower extremities. In addition to control of blood pressure etc.

    I would recommend this item to a friend.

     
  • By
    from Effingham, IL

      5
      •  
      •  
      •  
      •  
      •  

    10/16/2013

    Best Benfotiamine

    Best Benfotiamine really helps with deep sleep which is great to feel rested.

    I would recommend this item to a friend.

     
  • By
    from Coral Gables, FL

      5
      •  
      •  
      •  
      •  
      •  

    7/24/2013

    Benfotiamine is great

    Best Benfotiamine has a great source of Thiamin a B Vitamin necessary for the human body.

    I would recommend this item to a friend.

     
  • By
    from Waltham, Massachusetts

      5
      •  
      •  
      •  
      •  
      •  

    6/29/2013

    Best Benfotiamine 300 mg. 60 capsules

    I have always wanted to try Best Benfotiamine.

    Pros

      Highest potency great price free shipping !

    Cons

      nothing

    I would recommend this item to a friend.

     
  • By
    from Orlando, FL

      5
      •  
      •  
      •  
      •  
      •  

    5/30/2013

    Really helps my neuropathy!

    A friend recommended Best Benfotiamine for neuropathy. My left hand was number from neuropathy and I had neuropathic burning and stinging in both hands. I took Best Benfotiamine one tablet a day for three days and on the fourth day I awakened with my left hand no longer numb and the burning and stinging in both hands very much improved. Best Benfotiamine has had a near-miraculous effect.

    Pros

      It works!

    Cons

    I would recommend this item to a friend.

     

Displaying reviews 1-6 of 6

Questions About This Item

Ask a Question

Please ask any questions you may have about this specific product in the field below.

Your question(s) and our corresponding answer(s) will not be confidential and will be posted publically on this specific product page.

Additionally, PureFormulas is unable to directly recommend products in relation to specific health conditions. Please contact your trusted healthcare practitioner for direct product recommendations.

If you have any general questions regarding orders or our policies and programs, please contact our Customer Happiness Team @ 1.800.383.6008

Ask a Question