Best Acetyl L-Carnitine 588 mg 120 Capsules

  • Brand: Doctors Best
  • Item Number: DRB1013
  • Serving Size: 1 Capsule(s)
  • Servings per Container: 120
  • Amount per Container: 120 Capsules
  • Price per Serving: $0.17
  • Price per Unit*: $0.17
  • * Price Per Unit may reflect product's price per capsule, tablet, ounce, fluid ounce, etc.
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Regular Price: $39.99 $20.71
  • Availability: 5 In Stock
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  • MFG # DRB-00152
  • UPC # 753950001527
  • Science-based nutrition

    Dietary supplement

    Beneficial antioxidant protection

    Enhances alertness and mental focus

    Supports energy metabolism in the brain

    Keeps nerves healthy and in repair

    Decreases free radical production in the brain

    Acetyl-L-Carnitine (ALC) is a naturally occurring form of L-Carnitine‚ a vitamin-like nutrient synthesized in the body from the amino acids lysine and methionine. ALC plays a key role in the production of acetylcholine‚ an important neurotransmitter for brain and nerve cell function.

    Supports Cognitive Function

    ALC has been studied for its effect on cognitive performance and emotional health in the elderly. In a single-blind‚ placebo-controlled trial‚ 481 elderly subjects taking 1500 mg of ALC per day were found to have improved scores on a memory test assessing cognitive abilities after 90 days of ALC supplementation. In addition to being known for its effects on recognition and memory‚ placebo-controlled ALC research has also shown better scores in scales measuring the mood of elderly people.

    Supports Biosynthesis of Acetylcholine‚ a Key Neurotransmitter for Brain and Nerve Function

    Brain function requires coordinated communication between brain cells. Neurons (brain & nerve cells) communicate across tiny cell-to-cell gaps called synapses. The passage of an electrical impulse from one neuron to the next requires a neurotransmitter to act as a messenger to pass signals to adjacent neurons. When an electrical signal arrives at the synaptic junction‚ the neuron releases a neurotransmitter into the synapse. The neuron on the other side of the synapse contains receptors for the neurotransmitter (that will bind it)‚ triggering a series of chemical events to send a new electrical signal down the membrane of the receiving neuron. Neurotransmitters work together like an orchestra to transmit information throughout the brain and nervous system.

    Acetylcholine is the most abundant neurotransmitter in the body‚ regulating activities of vital organs and blood vessels‚ and communication between nerves and muscles. In the brain‚ acetylcholine helps to facilitate memory and learning‚ as well as influencing emotions. ALC is structurally similar to acetylcholine— enough so that brain neurons stimulated by acetylcholine are receptive to stimulation by ALC. In an experimental animal model‚ it was shown that ALC can furnish acetyl groups to be utilized during the natural biosynthesis of acetylcholine. ALC’s structural similarity to acetylcholine has led researchers to investigate its effects on mental function and emotional health.

    Helps Supply the Brain With Energy Through Mitochondrial Efficiency

    The acetyl groups donated by ALC can be used to naturally synthesize acetyl-CoA‚ the key substrate for energy metabolism in the mitochondrion. Acetyl-CoA enters the Krebs cycle‚ the mitochondrial pathway that generates cellular energy in the form of ATP. Age-related decreases in mitochondrial oxidative capacity are a well-known cause of aging‚ as the organelles and organs in the body begin to operate less efficiently without ideal ATP production. The effects of decreased mitochondrial oxidative capacity are especially prevalent in organs that require high-energy inputs‚ such as the brain and heart. Recent clinical studies have shown that ALC helps to promote and maintain healthy mitochondrial function.

    Helps Uphold the Integrity of Intracellular Membranes

    Phospholipids are structural components of brain cell membranes that regulate neuronal function. ALC has been shown to promote healthy membrane phospholipid metabolism in research subjects.8 Additionally‚ the acetyl groups in ALC are naturally utilized by the body to modify the activity of proteins in neuronal membranes. Through these means‚ ALC promotes normal membrane function‚ stability‚ and structural integrity.

    Supports Nerve Growth Factor Production

    The body produces specialized proteins called growth factors that are essential to the growth and repair of tissue. Nerve Growth Factor (NGF) prolongs the survival of neurons in both the central and peripheral nervous systems. As we age‚ our central nervous system experiences a decrease in the binding of NGF to neuron membranes. ALC has shown the ability to promote the maintenance of normal interactions between NGF and neuron membranes. 10 Given to aged rats‚ ALC demonstrated effectiveness in promoting normal levels of NGF‚ and it helped maintain utilization of the growth factor in the rats throughout the duration of the study. Maintaining ideal levels of NGF is essential for the health of cholinergic neurons (nerve cells stimulated by acetylcholine)‚ as cholinergic neurons lose some functional capacity due to a lack of NGF. In aged rats‚ ALC is known to promote the health of cholinergic neurons. In sum‚ such results suggest that ALC positively influences the maintenance of healthy and normal NGF activity.

    Supports Healthy Brain Neuron Function

    Several animal studies have revealed that ALC contains many biochemical characteristics that help neurons face the aging process optimally. ALC has been shown to raise levels of glutathione‚ a key antioxidant‚ in isolated mouse brain tissue. ALC also reduces blood levels of MDA (malondialdehyde)‚ a free radical byproduct. Furthermore‚ ALC is a chelator of iron: it acts as a molecule that can naturally sequester iron in the body to prevent iron-mediated oxidative damage to cells. As a whole‚ data from in vitro and animal studies suggest that ALC is effective towards the maintenance of healthy brain neurons and normal neuronal energetic processes. This hypothesis is supported by human studies that demonstrate the potential of ALC to promote healthy brain function in elderly persons.

    These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

Official Website:

Serving size: 1 Capsule

Servings Per Container: 120

Amount Per Serving %DV

Acetyl-L-Carnitine 500 mg †
(from 588mg acetyl-l-carnitine HCl supplied by Sigma tau)


† Daily Value not established.

Other Ingredients: Stearic acid‚ cellulose‚ magnesium silicate‚ silicon dioxide‚ gelatin (capsule).

Does Not Contain: milk‚ egg‚ wheat‚ gluten‚ corn‚ soy‚ sugar‚ sweeteners‚ starch‚ salt‚ or preservatives.

Take 1 to 4 capsules daily with or without food.

ALC is considered safe and well tolerated when consumed orally. Taken as directed by the label‚ the maximum daily dosage of this product is 4 capsules per day‚ well within the limits reported by human safety studies of ALC using the Observed Safety Level (OSL) method.

  • GMP Certification
  • Heavy Metals Free
  • Made In The Usa
  • Milk Free
  • Egg Free
  • Gluten Free
  • Corn Free
  • Soy Free
  • Wheat Free
  • Sugar Free
  • Starch Free
  • Salt Free
  • Preservative Free
  • Pesticide Free

Ratings & Reviews

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Overall Rating for Best Acetyl L-Carnitine 588 mg 120 Capsules

Based on 4 reviews

Displaying reviews 1-4 of 4

  • By Giovanni
    from Coral Gables, FL



    Good for heart

    Best Acetyl L-Carnitine is good for the cardiovascular system.

    I would recommend this item to a friend.

  • By Allie
    from Eugene, OR



    Cant tell if its working or not

    I have Chronic Fatigue Syndrome and follow some of Dr. Teitelbaums suggestions (see his book & website) which include taking Best Acetyl L-Carnitine together with L-Lysine. Since I am taking numerous supplements in addition to seeing an acupuncturist I am not sure what is doing what...but I do start to feel improvements overall.


      Good Price Non-GMO!


    I would recommend this item to a friend.

  • By Romina
    from Homestead, Florida



    Just as good as the expensive stuff

    We have been taking this vitamin for more than a month and we havent had any side effects. Similar to other expensive brands.


      Price and quality


    I would recommend this item to a friend.

  • By Maggie
    from Maryland



    Heart Health

    Im following Dr. Stephen Sinatras suggestions for good heart health and feel great. Best Acetyl L-Carnitine by Doctors Best is offered at a good price.

    I would recommend this item to a friend.


Displaying reviews 1-4 of 4

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