MFG # 206
UPC # 351953206019
Official Website: http://www.anaboliclabs.com
DESCRIPTION: A delicious berry-flavored small lozenge providing 1,000 mcg of methylcobalamin - the active form
of vitamin B12.
FORMULA:
Our B12-Plus Lozenges provide 1,000 mcg of methylcobalamin in each naturally-flavored lozenge. This specialized form of B12 is created by fermentation with a proprietary strain of bacteria, resulting in a high-potency, gluten-free, vegan form of this essential nutrient.
INDICATIONS:
Vitamin B12 is an essential nutrient for life, and deficiencies are not uncommon. Vitamin B12 deficiencies are associated with:
Nerve pain
Fatigue
Alcoholism
Chronic illness
Pregnancy
Improper vegetarian diets
B12 is indicated as a dietary supplement for:
Supporting energy production
Normalizing homocysteine synthesis
Promoting healthy cognitive function
Supporting the sleep-wake cycle
Elderly patients who often have deficiencies and/or higher requirements of this nutrient.
BACKGROUND:
Vitamin B12 helps maintain healthy nerve and red blood cells in humans and is needed to make DNA. Vitamin B12 is bound to proteins in food, and must be separated from protein in order to be used by the body. Hydrochloric acid
(HCl) in the stomach separates B12 from protein. Once released, B12 combines with a compound called intrinsic
factor (IF), which allows B12 to be absorbed into the bloodstream.
Humans can store several years' worth of vitamin B12 in the body. However, deficiency can result from being unable to use vitamin B12 from a defect in absorption, reduced intake of B12 (such as in vegans or strict vegetarians) or reduced ability to make HCl (occurs during the aging process). The most common inability to absorb vitamin B12 from the intestinal tract manifests as a disease known as pernicious anemia. Vitamin B12 deficiency can result in abnormal neurologic and psychiatric symptoms. According to the NIH’s Medline Plus, “these symptoms may occur when vitamin B12 levels are just slightly lower than normal.
Mechanisms of Action
The majority of the B12 circulating in blood is in the methyl form. The difference between cyano- and methylcobalamin is that cyano B12 has a cyanide group (CN) attached, whereas methyl B12 carries a methyl group (CH3). Before cyano B12 can be properly used by the body, it has to be stripped of its cyano group and 'reduced' (gain electrons). Once that is done, it is ready to take on a methyl group and be distributed throughout the body as methyl B12.
Cobalamin is reabsorbed from the bile each day. This explains why strict vegetarians who do not consume animal proteins can develop vitamin B12 deficiency after many years. However those with absorptive defects (e.g. stomach removal, bariatric surgery, or hereditary defects) show signs as quickly as 2-3 years. Intestinal bacteria are another source of internally produced cobalamin.
Homocysteine appears to accumulate in the body whenever B12 gets low, and this accumulation has been linked with increased risk of cardiovascular and Alzheimer's disease and osteoporosis. Folate and B12 are necessary cofactors for the enzymatic conversion of homocysteine to methionine.
Importance in homocysteine, SAM-e and fat metabolism regulation Methylcobalamin transfers the methyl portion to homocysteine to form methionine. Inadequate dietary intake of methyl groups leads to low methylation of important pathways such as disturbed hepatic protein (methionine) metabolism as determined by elevated plasma homocysteine concentrations and decreased S-adenosylmethionine (SAM-e) concentrations, and inadequate hepatic fat metabolism, which leads to steatosis (fatty accumulation) and ensuing plasma dyslipidemia. Such disturbed liver metabolism may lead to coronary, cerebral, hepatic, and vascular diseases.
Brain Health
Homocysteine is harmful to neurons and blood vessels, including the cerebral microvasculature. It is possible that
such effects contribute to the cascade of events that leads to cognitive decline, dementia, and depression in later life.
Sleep-Wake Cycle Effects
One double-blind, placebo-controlled study looked at methylcobalamin’s role in circadian rhythm disorders. High
doses (6 mg/day) of methylcobalamin showed some benefits (although not statistically significant) compared to
placebo at the 8th week. Benefits were defined as improved mood at waking and less daytime sleepiness.
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
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