- MFG # 9420
- UPC # 629022094202
Vitamin B12 is the cofactor in enzymatic reactions with diverse physiological functions. It is required for the conversion of methylmalonyl CoA to succinyl CoA‚ as well as the conversion of homocysteine to methionine by methionine synthase‚ which is then converted into S-adenosylmethionine. A B12 deficiency causes impairments in both of these pathways‚ disrupting neurological function‚ including poor formation of myelin nerve sheaths‚ production of toxic levels of homocysteine‚ and inefficient energy production in all cells.
Cobalamin is also required to remove the methyl group from methyltetrahydrofolate and generate tetrahydrofolate‚ a necessary step in DNA synthesis. As a consequence‚ B12 deficiency affects the growth‚ function‚ and repair of all cells‚ the most apparent sign of which is megaloblastic anemia‚ caused by inhibited mitosis of red blood cells.
Some individuals‚ especially those with malabsorption or low dietary intake‚ are at higher risk for a B12 deficiency. Sublingual B12 at a dose of 1‚000 mcg per day bypasses active absorption routes‚ and can restore normal B12 levels even in those with pernicious anemia and/or impaired absorptive capacity.
Superior to the more common form‚ cyanocobalamin as cyanocobalamin does not convert to enough methylcobalamin to correct some forms of anemia‚ neurological defects‚ and aging
Methylcobalamin is the active form of vitamin B12 for maximum benefit
Lozenges allow for fast acting delivery system directly into blood stream
Lowers homocystein levels for protective cardiovascular benefits
Drug Interactions: Although several classes of drugs‚ such as aminoglycosides‚ anticonvulsants‚ bile acid sequestrants‚ and proton pump inhibitors are known to either interfere with B12 absorption or function‚ there are no known negative interactions caused by B12 supplementation with any medications. B12 may enhance the function ore reduce the adverse effects of several medication classes‚ such as SSRIs and oral contraceptives.
Although there is inadequate evidence to support the following drug interactions‚ caution should be taken. The following drugs may interfere with the absorption or utilization of vitamin B12: Antibiotics‚ Aldomet®‚ Atromid-S®‚ Azidothymidine (AZT)‚ Azulfidine®‚ birth control pills‚ Cimetidine (Tagamet®)‚ Metformin (Glucophage®)‚ Isoniazid (Laniazid®)‚ Pepcid®‚ Prevacid®‚ Prilosec®‚ Ranitidine (Zantac®).
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 lozenge
Servings per Container: 60
1 Lozenge Provides:
Vitamin B12 (as methylcobalamin).................................................. 1‚000 mcg
Other Ingredients: Lactose (from milk)‚ cellulose‚ croscarmellose sodium‚ magnesium stearate (vegetable grade).
Product contains no: artificial preservatives‚ colors or sweeteners; no corn‚ soy‚ gluten‚ starch‚ wheat or yeast.
1 lozenge per day or as directed by a health care professional. Chew or hold in mouth until dissolved.
B12 is contraindicated in patients with hereditary optic neuropathy‚ and may be cautioned against at high doses in oncology patients because of its role in DNA synthesis. Supplemental folic acid may mask a B12 deficiency‚ which should be ruled out‚ and folic acid and increased potassium intake is recommended with B12 therapy. B12 is considered safe in pregnant and lactating women‚ and may be indicated in children with a low dietary intake.
Allergy / Dietary Needs
- GMP Certification
- Organic Product
- Artificial Color Free
- Artificial Flavor Free
- Artificial Sweetener Free
- Corn Free
- Gluten Free
- Soy Free
- Starch Free
- Wheat Free
- Yeast Free
- Artificial Preservative Free