Domestic orders placed by 5 PM Eastern Time will be packed and shipped the
same day, pending verification of billing information and the shipping
Orders containing refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
If an item on your order is on backorder we will notify you by email
and we will ship what we have in stock, the backordered item (s) will be
shipped as soon as it is back in stock (usually within 1 week or less)
Excludes all orders placed during weekends and on major US holidays(Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day)
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Order before 5 p.m. EST and this item will ship out today. Except during weekends and holidays.
We’re fast like that. Place your order before 5 p.m. and it will ship the same day, as long as we can verify billing and shipping information. Refrigerated items will be processed quickly, but might not ship the same day.
If it’s backordered, we’ll notify you by email and will ship it when it’s available (usually 1 week or less).
Vitamin B12 is the cofactor in enzymatic reactions with diverse physiological functions. It is required for the conversion of methylmalonyl CoA to succinyl CoA‚ as well as the conversion of homocysteine to methionine by methionine synthase‚ which is then converted into S-adenosylmethionine. A B12 deficiency causes impairments in both of these pathways‚ disrupting neurological function‚ including poor formation of myelin nerve sheaths‚ production of toxic levels of homocysteine‚ and inefficient energy production in all cells.
Cobalamin is also required to remove the methyl group from methyltetrahydrofolate and generate tetrahydrofolate‚ a necessary step in DNA synthesis. As a consequence‚ B12 deficiency affects the growth‚ function‚ and repair of all cells‚ the most apparent sign of which is megaloblastic anemia‚ caused by inhibited mitosis of red blood cells.
Some individuals‚ especially those with malabsorption or low dietary intake‚ are at higher risk for a B12 deficiency. Sublingual B12 at a dose of 1‚000 mcg per day bypasses active absorption routes‚ and can restore normal B12 levels even in those with pernicious anemia and/or impaired absorptive capacity.
Benefits Superior to the more common form‚ cyanocobalamin as cyanocobalamin does not convert to enough methylcobalamin to correct some forms of anemia‚ neurological defects‚ and aging Methylcobalamin is the active form of vitamin B12 for maximum benefit Lozenges allow for fast acting delivery system directly into blood stream Lowers homocystein levels for protective cardiovascular benefits
Additional Information Drug Interactions: Although several classes of drugs‚ such as aminoglycosides‚ anticonvulsants‚ bile acid sequestrants‚ and proton pump inhibitors are known to either interfere with B12 absorption or function‚ there are no known negative interactions caused by B12 supplementation with any medications. B12 may enhance the function ore reduce the adverse effects of several medication classes‚ such as SSRIs and oral contraceptives.
Although there is inadequate evidence to support the following drug interactions‚ caution should be taken. The following drugs may interfere with the absorption or utilization of vitamin B12: Antibiotics‚ Aldomet®‚ Atromid-S®‚ Azidothymidine (AZT)‚ Azulfidine®‚ birth control pills‚ Cimetidine (Tagamet®)‚ Metformin (Glucophage®)‚ Isoniazid (Laniazid®)‚ Pepcid®‚ Prevacid®‚ Prilosec®‚ Ranitidine (Zantac®).
These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
Serving Size: 1 lozenge Servings per Container: 60
1 Lozenge Provides: Vitamin B12 (as methylcobalamin).................................................. 1‚000 mcg
Product contains no: artificial preservatives‚ colors or sweeteners; no corn‚ soy‚ gluten‚ starch‚ wheat or yeast.
1 lozenge per day or as directed by a health care professional. Chew or hold in mouth until dissolved.
B12 is contraindicated in patients with hereditary optic neuropathy‚ and may be cautioned against at high doses in oncology patients because of its role in DNA synthesis. Supplemental folic acid may mask a B12 deficiency‚ which should be ruled out‚ and folic acid and increased potassium intake is recommended with B12 therapy. B12 is considered safe in pregnant and lactating women‚ and may be indicated in children with a low dietary intake.
PureFormulas is your one-stop shop for health supplements, vitamins, minerals and other nutritional supplements. We carry thousands of products from a huge variety of prescreened manufacturers because our goal is to help you achieve optimal health, regardless of your age, lifestyle or location.
At PureFormulas, we hand pick every item in our inventory. We only work with the most reputable, trusted manufacturers of vitamins, minerals and nutritional supplements.
When you order from PureFormulas, you're getting access to our large inventory, the convenience of fast, free shipping, and the comfort of knowing your order is guaranteed authentic and fresh. Our dedicated team is here to make sure you have access to the best health supplements, vitamins and minerals and other nutritional supplements. Our friendly, efficient customer service is second-to-none, and we guarantee your satisfaction on every order you place through PureFormulas.
We invite you to browse our large selection of vitamins and minerals, nutritional supplements and other health supplements, and please contact us if you have any questions. We look forward to meeting your needs today!
Domestic orders placed by 5 PM Eastern Time will be packed and shipped the same day, pending verification of billing information and the shipping method selected. Orders containing out-of-stock items or refrigerated items will be processed as quickly as possible, but won't necessarily be shipped out the same day.
Excludes all orders placed during weekends and on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day).